51421-34-2

Basic information

• Product Name: (3-TRIFLUOROMETHYL-BENZYL)-HYDRAZINE
• Synonyms: (3-TRIFLUOROMETHYL-BENZYL)-HYDRAZINE;3-Trifluoromethylbenzylhy...;{[3-(trifluoromethyl)phenyl]methyl}hydrazine
• CAS NO: 51421-34-2
• Molecular Formula: C₈H₉F₃N₂
• Molecular Weight: 190.17
• Mol File: 51421-34-2.mol

Chemical Properties

• Boiling Point: 256.4°C at 760 mmHg
• Flash Point: 108.9°C
• Appearance: /
• Density: 1.253g/cm³
• Vapor Pressure: 0.0154mmHg at 25°C
• Refractive Index: 1.482
• CAS DataBase Reference: (3-TRIFLUOROMETHYL-BENZYL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-TRIFLUOROMETHYL-BENZYL)-HYDRAZINE(51421-34-2)
• EPA Substance Registry System: (3-TRIFLUOROMETHYL-BENZYL)-HYDRAZINE(51421-34-2)

Safety Data

• Hazardous Substances Data: 51421-34-2(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
(3-TRIFLUOROMETHYL-BENZYL)-HYDRAZINE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure, including the trifluoromethyl and benzyl groups, may contribute to the development of new drugs with improved properties, such as increased potency or selectivity.
Used in Agricultural Chemistry:
(3-TRIFLUOROMETHYL-BENZYL)-HYDRAZINE is used as a precursor in the production of certain pesticides. The hydrazine functional group in its structure may be utilized to create agrochemicals with enhanced efficacy or reduced environmental impact.
Note: The specific uses or properties of (3-TRIFLUOROMETHYL-BENZYL)-HYDRAZINE are not immediately available, and the above uses are based on the general relevance of organofluorine compounds and hydrazine in the mentioned fields. Further research and development may be required to fully explore and validate its potential applications.

InChI:InChI=1/C8H9F3N2/c9-8(10,11)7-3-1-2-6(4-7)5-13-12/h1-4,13H,5,12H2

Upstream product

• 705-29-3 3-Trifluoromethylbenzyl chloride 

Downstream Products

• 1392323-75-9 C₂₀H₂₁ClF₃N₃O₂ 
• 1392323-88-4 C₂₁H₂₂Cl₂F₃N₃O₂ 
• 1392324-02-5 C₂₁H₂₃ClF₃N₃O₂ 
• 1392324-12-7 C₂₂H₂₅ClF₃N₃O₂ 
• 112914-88-2 1-(3-trifluoromethylbenzyl)-3-methylmercapto-4-cyano-5-amino-pyrazole 

Relevant articles and documents

Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives

The discovery of new safe and effective pesticides is one of the main means of providing eco-friendly agricultural agents for modern crop protection. To identify new biological molecules based of the anthranilic diamide skeleton of the novel pesticide chlorantraniliprole, which acts on the ryanodine receptor and functional groups in acyl hydrazine insect growth regulators, more than 40 new compounds of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives were designed and synthesized. The structures of the new compounds were characterized using 1H nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HRMS), or electron impact mass spectrometry (EI-MS), and their biological activities at a concentration of 600 mg L -1 were determined against cotton aphid (Aphis gossypii Glover), carmine spider mite (Tetranychus cinnabarinus), and diamondback moth (Plutella xylostella). The results of a preliminary assay showed that compounds 6a-I-2 and 6d-III-4 maintained the lethal activity of anthranilic diamide against P. xylostella; compounds 6c-II-4, 6d-I-7, 6d-II-1, and 6d-III-5 exhibited good lethal activity against A. gossypii; and compounds 6a-II-1, 6a-III-1, 6b-I-7, 6c-I-1, and 6c-III-5 retained promising larvicidal activities against T. cinnabarinus. In subsequent further tests against T. cinnabarinus, compounds 6a-II-1, 6a-III-1, 6c-I-1, and 6c-III-5 showed an LC50 value of -1; especially, the LC50 of compound 6a-III-1 was only 27.9 mg L-1. In conclusion, the introduction of the functional fragment-substituted acyl hydrazine improved the acaricidal activity of the anthranilic diamide skeleton, and the halogen atom at X position and the methyl group at R1 play crucial roles in the biological activities of the compounds.

ADENOSINE A2A RECEPTOR ANTAGONISTS

Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein: X1 and X2 are 1-3 substituents independently selected from the group consisting of H, alkyl, halo, —CF3, —OCF3, alkoxy, —OH and —CN;n is 0, 1 or 2; andR and R1 are H or alkyl; also disclosed is the use of the compounds in the treatment of CNS diseases such as Parkinson's disease, alone or in combination with other agents for treating CNS diseases, pharmaceutical compositions comprising them and kits comprising the components of the combinations.