514218-73-6Relevant academic research and scientific papers
Design, synthesis, and antiproliferative activity assessment of non-ATP-competitive fibroblast growth factor receptor 1 inhibitors
Ying,Wang, Jia,Xu,Kang,Zhang,Shi,Fan,Wang,Zhou,Wu,Wu,Li,Liang
, p. 2744 - 2751 (2016)
Fibroblast growth factor receptor 1 (FGFR1) is considered a therapeutic target for multiple cancers, including gastric cancer. FGFR1 inhibitors, being ATP competitors, can prevent the kinase domain and the downstream signaling cascade from phosphorylation
