51430-74-1

Basic information

• Product Name: (5-amino-2-phenyl-1,3-dioxan-5-yl)methanol
• CAS NO: 51430-74-1
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.2417
• Mol File: 51430-74-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 359.6°C at 760 mmHg
• Flash Point: 171.3°C
• Density: 1.18g/cm³
• Vapor Pressure: 8.47E-06mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: (5-amino-2-phenyl-1,3-dioxan-5-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (5-amino-2-phenyl-1,3-dioxan-5-yl)methanol(51430-74-1)
• EPA Substance Registry System: (5-amino-2-phenyl-1,3-dioxan-5-yl)methanol(51430-74-1)

Safety Data

• Hazardous Substances Data: 51430-74-1(Hazardous Substances Data)

Usage

General Description

"(5-amino-2-phenyl-1,3-dioxan-5-yl)methanol" is a synthetic chemical compound with a molecular formula C11H15NO3. It is a white solid substance with a molecular weight of 209.24 g/mol. This chemical is primarily used as an intermediate in the pharmaceutical industry for the synthesis of various drugs and pharmaceutical compounds. It is also utilized in laboratory research and other chemical processes. The compound's structure contains an amino group, a phenyl group, and a dioxane ring, making it a versatile building block for the production of a variety of organic molecules. Additionally, it is important to handle this compound with care as it may pose potential health hazards and should be used in accordance with proper safety protocols.

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 1185-53-1 tris hydrochloride 
• 51430-71-8 2-phenyl-5-(hydroxymethyl)-5-nitro-1,3-dioxane 

Downstream Products

• 154627-61-9 5-tert-butoxycarbonylamino-5-hydroxymethyl-2-phenyl-1,3-dioxane 
• 52941-82-9 2-phenyl-1,3-dioxan-5-one 
• 102654-38-6 2-phenyl-1,3-dioxan-5,5-diol 
• 53159-33-4 5-hydroxy-5-methyl-2-phenyl-1,3-dioxane 
• 1611466-56-8 5-methyl-5-(t-butyldimethylsilanoyl)-2-phenyl-1,3-dioxane 
• 1611466-28-4 3-(benzyloxy)methyl-2-methyl-2-(t-butyldimethylsilyl)propanol 
• 1611465-64-5 3-(benzyloxymethyl)-2-methyl-2-(t-butyldimethylsilyl)propanal 
• 145022-69-1 C₄₉H₇₁N₉O₁₅ 
• 79997-91-4 5-methylene-2-phenyl-1,3-dioxan-7,7-d2 
• 4141-24-6 trans-2-phenyl-1,3-dioxan-5-ol acetate 
• 1708-40-3 cis-5-hydroxyl-2-phenyl-1,3-dioxane 
• 1708-40-3 trans-2-phenyl-1,3-dioxan-5-ol 

Relevant articles and documents

Stereocontrol by quaternary centres: A stereoselective synthesis of (-)-luminacin D

Very high diastereoselectivity can be achieved by 1,3-chelation-controlled allylation of aldehydes that possess a non-chelating α-ether substituent, even if the α-position is a quaternary centre and/or a spiro-epoxide. This reaction was used as a key step in an enantioselective synthesis of the angiogenesis inhibitor luminacin D.

1,3-Dioxan-5-ones: synthesis, deprotonation, and reactions of their lithium enolates

A general synthetic route to 2-alkyl- and 2,2-dialkyl-1,3-dioxan-5-ones, using tris(hydroxymethyl)nitromethane as the starting material, is described.Deprotonation of these compounds was studied.It was established that these dioxanones could be deprotonated with LDA; however, the reduction of the carbonyl group via a hydride transfer from LDA, giving the corresponding dioxanols, often competed with deprotonation.The reduction could be minimized by using Corey's internal quench procedure to form silyl enol ethers and was less pronounced in 2,2-dialkyldioxanones (ketals) than in 2-alkyldioxanones (acetals).Self-aldol products were observed when dioxanone lithium enolates were quenched with H2O.Addition reactions of lithium enolates of dioxanones to aldehydes were threo-selective as predicted by the Zimmerman-Traxler model.Dioxanones having two different alkyl groups at the 2-position were deprotonated enantioselectively by chiral lithium amide bases with enantiomeric excess (ee) of up to 70percent. - Key words: 1,3-dioxan-5-ones, enantioselective deprotonation, chiral lithium amides.

The total synthesis of antrimycin D(v)

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