154627-61-9Relevant academic research and scientific papers
Synthesis of fluorinated analogues of the immunosuppressive drug FTY720
Ko, Rebecca Y. Y.,Chu, John C. K.,Chiu, Pauline
experimental part, p. 2542 - 2547 (2011/04/25)
Four fluorinated derivatives of the immunosuppressive drug FTY720 were synthesized by a convergent strategy, using the Sonogashira coupling as the key reaction to assemble the two major fragments.
A convergent synthesis of the immunosuppressant FTY720 employing aqueous Wittig chemistry
Calzavara, Janice,McNulty, James
supporting information; experimental part, p. 5672 - 5675 (2011/11/06)
A short, convergent synthesis of the immunosuppressant FTY720 is described involving the use of 4-hydroxymethylbenzaldehyde as a pivotal intermediate. A double Wittig strategy was developed to connect this dual-functional aldehyde with an alkyl-tether and to a readily available TRIS-derivative leading to an efficient synthesis of the target molecule.
The total synthesis of antrimycin D(v); III: Construction of the protected hexapeptide and deprotection
Schmidt,Riedl
, p. 815 - 818 (2007/10/02)
In the preceding communication we described the synthesis of tetrahydropyridazine-3-carboxylic acids and their incorporation into peptides. We have also prepared the tripeptide 2 which is contained in the antibiotic antrimycin D(v) 15. We now report on th
