51432-36-1Relevant articles and documents
A SIMPLE AND GENERAL ENTRY TO 5-SUBSTITUTED URUDINES BASED ON THE REGIOSELECTIVE LITHIATHION CONTROLLED BY A PROTECTING GROUP IN THE SUGAR MOIETY
Hayakawa, Hiroyuki,Tanaka, Hiromichi,Obi, Kikoh,Itoh, Masayuki,Miyasaka, Tadashi
, p. 87 - 90 (2007/10/02)
Lithiathion of 2',3',5'-tris-O-(tert-butyldimethylsilyl)uridine with sec-BuLi/TMEDA occurs at the C-5 position with a high regioselectivity and subsequent reactions of the resulting C-5 lithiated species with a variety of electrophiles provides a general entry to 5-substituted uridines.