51437-89-9

Usage

Uses

Used in Surfactant Applications:
2-(4-OCTYLPHENOXY)ETHANOL is used as a nonionic surfactant for its ability to reduce the surface tension of water, enhancing the solubility of hydrophobic compounds and improving the stability of emulsions and foams.
Used in Cleaning Products Industry:
In the cleaning products industry, 2-(4-OCTYLPHENOXY)ETHANOL is used as an ingredient in detergents, cleaners, and shampoos for its effective cleaning properties and ability to create a rich lather.
Used in Textile Industry:
2-(4-OCTYLPHENOXY)ETHANOL is used as a surfactant in the textile industry for its wetting, spreading, and emulsifying properties, which aid in the processing of fibers and the application of dyes and finishes.
Used in Personal Care Industry:
In the personal care industry, 2-(4-OCTYLPHENOXY)ETHANOL is used as an ingredient in cosmetics and personal care products for its emulsifying and solubilizing properties, which help to create stable formulations and improve the texture and feel of the products.
Used in Industrial Applications:
2-(4-OCTYLPHENOXY)ETHANOL is used in various industrial applications, such as in the manufacturing of paints, coatings, and lubricants, for its ability to improve the performance and stability of these products.
Used in Agricultural Industry:
In the agricultural industry, 2-(4-OCTYLPHENOXY)ETHANOL is used as a surfactant in agrochemical formulations to enhance the effectiveness of pesticides and herbicides by improving their spread and absorption on plant surfaces.

InChI:InChI=1/C16H26O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-14-13-17/h9-12,17H,2-8,13-14H2,1H3

Upstream product

• 1806-26-4 p-Octylphenol 
• 1621517-92-7 ethyl 2-(4-octylphenoxy)acetate 

Downstream Products

• 1621517-96-1 2-(tert-butyldimethylsilyloxy)-3-(4-octylphenoxy)propanenitrile 
• 1621517-98-3 2-(tert-butyldimethylsilyloxy)-3-(4-octylphenoxy)propanamide 
• 1621518-00-0 2-(tert-butyldimethylsilyloxy)-3-(4-octylphenoxy)propanethioamide 
• 1621518-02-2 ethyl 2-(2-(1-hydroxy-2-(4-octylphenoxy)ethyl)thiazol-4-yl)acetate 
• 1621518-07-7 methyl 2-(1-((tert-butyldimethylsilyl)oxy)-2-(4-octylphenoxy)ethyl)thiazole-4-carboxylate 
• 1621518-08-8 methyl 2-(1-hydroxy-2-(4-octylphenoxy)ethyl)thiazole-4-carboxylate 
• 1621517-94-9 2-(4-octylphenoxy)-1-(thiazol-2-yl)ethanol 
• 1621517-95-0 1-(benzo[d]thiazol-2-yl)-2-(4-octylphenoxy)ethanol 
• 1621517-48-3 2-(4-octylphenoxy)-1-(thiazol-2-yl)ethanone 
• 1621517-49-4 1-(benzo[d]thiazol-2-yl)-2-(4-octylphenoxy)ethanone 
• 1621517-52-9 ethyl 2-(2-(2-(4-octylphenoxy)acetyl)thiazol-4-yl)acetate 
• 1626404-73-6 methyl 2-(1-(tert-butyldimethylsilyloxy)-2-(4-octylphenoxy)ethyl)-4,5-dihydrothiazole-4-carboxylate 
• 1621517-53-0 methyl 2-(2-(4-octylphenoxy)acetyl)thiazole-4-carboxylate 

Relevant academic research and scientific papers

ANTIINFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS

A compound of formula (I) wherein X is O, C O or S; Y is N or CH; R2 and R4 are each independently H, -(CH2)pCOOH, -(CH2)pCON(R5)2 or - (CH2)pCOOC 1-6alkyI; or R2 and R4 together form a 6-membered phenyl ring fused to the five membered ring; each R1 is independently selected from H, halo (e.g. fluoro or chloro), C6-10aryl, C7-12arylalkyl, C2-12alkenyl; OC1-2 alkyl, OC2-12 aikenyl or a C1-12 alkyl group; each R5 is H or C1-6 alkyl; each p is 0 to 3; n is 1 to 4; or a salt, ester, solvate, N-oxide, or prodrug thereof, e.g. a salt thereof.

Inhibition of group IVA cytosolic phospholipase A2by thiazolyl ketones in vitro, ex vivo, and in vivo

Group IVA cytosolic phospholipase A2(GIVA cPLA2) is the rate-limiting provider of pro-inflammatory mediators in many tissues and is thus an attractive target for the development of novel anti-inflammatory agents. In this work, we present the synthesis of new thiazolyl ketones and the study of their activities in vitro, in cells, and in vivo. Within this series of compounds, methyl 2-(2-(4-octylphenoxy)acetyl)thiazole-4-carboxylate (GK470) was found to be the most potent inhibitor of GIVA cPLA2, exhibiting an XI(50) value of 0.011 mole fraction in a mixed micelle assay and an IC50of 300 nM in a vesicle assay. In a cellular assay using SW982 fibroblast-like synoviocytes, it suppressed the release of arachidonic acid with an IC50value of 0.6 μM. In a prophylactic collagen-induced arthritis model, it exhibited an anti-inflammatory effect comparable to the reference drug methotrexate, whereas in a therapeutic model, it showed results comparable to those of the reference drug Enbrel. In both models, it significantly reduced plasma PGE2levels.