1621517-92-7

Basic information

• Product Name: ethyl 2-(4-octylphenoxy)acetate
• Synonyms: ethyl 2-(4-octylphenoxy)acetate
• CAS NO: 1621517-92-7
• Molecular Weight: 292.419
• Mol File: 1621517-92-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-octylphenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-octylphenoxy)acetate(1621517-92-7)
• EPA Substance Registry System: ethyl 2-(4-octylphenoxy)acetate(1621517-92-7)

Safety Data

• Hazardous Substances Data: 1621517-92-7(Hazardous Substances Data)

Upstream product

• 1806-26-4 p-Octylphenol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 51437-89-9 2-(4-octylphenoxy)ethanol 
• 1621517-94-9 2-(4-octylphenoxy)-1-(thiazol-2-yl)ethanol 
• 1621517-95-0 1-(benzo[d]thiazol-2-yl)-2-(4-octylphenoxy)ethanol 
• 1621517-48-3 2-(4-octylphenoxy)-1-(thiazol-2-yl)ethanone 
• 1621517-49-4 1-(benzo[d]thiazol-2-yl)-2-(4-octylphenoxy)ethanone 
• 1621517-96-1 2-(tert-butyldimethylsilyloxy)-3-(4-octylphenoxy)propanenitrile 
• 1621517-98-3 2-(tert-butyldimethylsilyloxy)-3-(4-octylphenoxy)propanamide 
• 1621518-00-0 2-(tert-butyldimethylsilyloxy)-3-(4-octylphenoxy)propanethioamide 
• 1621518-02-2 ethyl 2-(2-(1-hydroxy-2-(4-octylphenoxy)ethyl)thiazol-4-yl)acetate 
• 1621517-52-9 ethyl 2-(2-(2-(4-octylphenoxy)acetyl)thiazol-4-yl)acetate 
• 1626404-73-6 methyl 2-(1-(tert-butyldimethylsilyloxy)-2-(4-octylphenoxy)ethyl)-4,5-dihydrothiazole-4-carboxylate 
• 1621518-07-7 methyl 2-(1-((tert-butyldimethylsilyl)oxy)-2-(4-octylphenoxy)ethyl)thiazole-4-carboxylate 
• 1621518-08-8 methyl 2-(1-hydroxy-2-(4-octylphenoxy)ethyl)thiazole-4-carboxylate 
• 1621517-53-0 methyl 2-(2-(4-octylphenoxy)acetyl)thiazole-4-carboxylate 

Relevant articles and documents

Inhibition of group IVA cytosolic phospholipase A2by thiazolyl ketones in vitro, ex vivo, and in vivo

Group IVA cytosolic phospholipase A2(GIVA cPLA2) is the rate-limiting provider of pro-inflammatory mediators in many tissues and is thus an attractive target for the development of novel anti-inflammatory agents. In this work, we present the synthesis of new thiazolyl ketones and the study of their activities in vitro, in cells, and in vivo. Within this series of compounds, methyl 2-(2-(4-octylphenoxy)acetyl)thiazole-4-carboxylate (GK470) was found to be the most potent inhibitor of GIVA cPLA2, exhibiting an XI(50) value of 0.011 mole fraction in a mixed micelle assay and an IC50of 300 nM in a vesicle assay. In a cellular assay using SW982 fibroblast-like synoviocytes, it suppressed the release of arachidonic acid with an IC50value of 0.6 μM. In a prophylactic collagen-induced arthritis model, it exhibited an anti-inflammatory effect comparable to the reference drug methotrexate, whereas in a therapeutic model, it showed results comparable to those of the reference drug Enbrel. In both models, it significantly reduced plasma PGE2levels.