51442-80-9Relevant articles and documents
Efficient preparation of vinylcyclopropane by S(N') cyclization of the organolithium derived from (E)5-iodo-1-methoxy-2-pentene
Bailey, William F.,Tao, Yong
, p. 6157 - 6158 (1997)
(5-Methoxy-E-3-pentenyl)lithium (1), which may be prepared in virtually quantitative yield from the corresponding iodide by low-temperature lithium-iodine exchange, cyclizes with expulsion of the allylic methoxy on warming in the presence of TMEDA to afford vinylcyclopropane in 88% yield.
All-(Z)-cyclooctadeca-1,4,7,10,13,16-hexaene: Structure and first preparation via an intramolecular Wittig reaction
Guiard, Sophie,Santelli, Maurice,Parrain, Jean-Luc
, p. 8099 - 8101 (2002)
The first synthesis of all-(Z)-cyclooctadeca-1,4,7,10,13,16-hexaene was achieved using an intramolecular Wittig reaction as a key step. The structure was firmly established by X-ray analysis.
A SIMPLE ORGANOCOBALT MEDIATED SYNTHESIS OF SUBSTITUTED 3-OXABICYCLOOCT-6-EN-7-ONES
Billington, David C.,Willison, Debra
, p. 4041 - 4044 (1984)
A range of substituted propargyl alcohols form ethers with allyl bromide in good yields; conversion of these ethers to the alkyne hexacarbonyl dicobalt complexes using Co2(CO)8, followed by intramolecular cyclisation gives substituted 3-oxabicyclooct-6-en-7-ones (4a-4e) in fair to moderate yields.
BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE
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Paragraph 1237-1238, (2019/10/23)
The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
Transannular Claisen rearrangement reactions for the synthesis of vinylcyclobutanes: Formal synthesis of (±)-grandisol
Craig, Donald,Funai, Kiyohiko,Gore, Sophie J.,Kang, Albert,Mayweg, Alexander V.W.
supporting information; experimental part, p. 8000 - 8002 (2012/01/04)
Unsaturated eight-membered lactones undergo decarboxylative and non-decarboxylative transannular Ireland-Claisen rearrangement reactions, to give substituted vinylcyclobutanes. A formal synthesis of (±)-grandisol is described. The Royal Society of Chemist
