51445-67-1

Upstream product

• 1279712-70-7 C₁₃H₁₇ClOS₂ 
• 10359-09-8 2-(4-chlorophenyl)-1,3-dithiane 
• 104-88-1 4-chlorobenzaldehyde 
• 123-38-6 propionaldehyde 

Downstream Products

• 1279712-78-5 (Z)-N-(1-(4-chlorophenyl)-1-oxobut-2-en-2-yl)acetamide 
• 1421479-12-0 4-ethyl-3-(4-chlorophenyl)-1,2,5-thiadiazole-1,1-dioxide 
• 1421479-13-1 (Z)-4-ethylidene-3-(4-chlorophenyl)-1,2,5-thiadiazoline-1,1-dioxide 
• 1421479-22-2 (S)-4-ethyl-3-(4-chlorophenyl)-4,5-dihydro-1,2,5-thiadiazoline-1,1-dioxide 
• 1421479-23-3 3-ethyl-4-(4-chlorophenyl)-4,5-dihydro-1,2,5-thiadiazoline-1,1-dioxide 

Relevant academic research and scientific papers

Enantioselective synthesis of 3,4-disubstituted cis- and trans-1,2,5-thiadiazolidine-1,1-dioxides as precursors for chiral 1,2-diamines

Both, cis- and trans-3,4-disubstituted thiadiazolidines 5 and 6 can enantioselectively be obtained from thiadiazoles 2 which, in turn, are efficiently prepared from the respective 1,2-diketone by an improved protocol. An asymmetric ruthenium-catalyzed transfer hydrogenation followed by a diastereoselective hydride addition furnishes exclusively the cis-isomers 5 which, under acidic conditions, undergo a novel isomerization into the trans-isomers 6. These cyclic sulfamides can be transformed into 1,2-diamines as well as 2,3-diamino acids.

New synthetic strategy for high-enantiopurity N-protected α-amino ketones and their derivatives by asymmetric hydrogenation

Asymmetric hydrogenation of α-dehydroamino ketones catalyzed by a rhodium-chiral phosphorus ligand complex (up to 99% ee, 1000 TON), represents an efficient approach to chiral α-amino ketones. The reduction of α-amino ketones catalyzed by palladium on carbon (Pd/C) leads to amphetamine precursors with quantitative yield and no significant enantioselectivity loss.