51454-64-9 Usage
Uses
Used in Pharmaceutical Industry:
2-(Chloromethyl)isonicotinonitrile is utilized as a key intermediate in the synthesis of biologically active molecules, playing a crucial role in the development of new drugs due to its ability to contribute to the formation of diverse medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Chloromethyl)isonicotinonitrile is employed as an intermediate in the production of herbicides and pesticides, thereby contributing to the development of agricultural products that enhance crop protection and yield.
Overall, 2-(Chloromethyl)isonicotinonitrile is a significant chemical intermediate that facilitates advancements in both pharmaceutical and agrochemical fields, underscoring its importance in the creation of new and effective products.
Check Digit Verification of cas no
The CAS Registry Mumber 51454-64-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,4,5 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 51454-64:
(7*5)+(6*1)+(5*4)+(4*5)+(3*4)+(2*6)+(1*4)=109
109 % 10 = 9
So 51454-64-9 is a valid CAS Registry Number.
51454-64-9Relevant academic research and scientific papers
METHOD FOR PREPARING LARGAZOLE ANALOGS AND USES THEREOF
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Paragraph 00355, (2016/09/26)
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
Modular synthesis and biological activity of pyridyl-based analogs of the potent Class i Histone Deacetylase Inhibitor Largazole
Clausen, Dane J.,Smith, William B.,Haines, Brandon E.,Wiest, Olaf,Bradner, James E.,Williams, Robert M.
, p. 5061 - 5074 (2015/08/03)
The formation of a series of analogs containing a pyridine moiety in place of the natural thiazole heterocycle, based on the potent, naturally occurring HDAC inhibitor Largazole has been accomplished. The synthetic strategy was designed modularly to access multiple inhibitors with different aryl functionalities containing both the natural depsipeptide and peptide isostere variant of the macrocycle. The cytotoxicity and biochemical activity of the library of HDAC inhibitors is described herein.
