51457-93-3Relevant academic research and scientific papers
Synthesis of 3-hydroxypyrimidine-2,4-diones. Addition of anilines to benzyloxy isocyanate synthons to give N-hydroxyureas
Romine,Martin,Meanwell,Epperson
, p. 846 - 850 (1994)
A new method, the addition of N-benzyloxychloroformate to methyl anthranilate followed by base-catalyzed cyclization, has been employed to synthesize the N-hydroxyquinazolinedione 1 and heterocyclic derivatives. N-Benzyloxycarbonylimidazole is a useful sy
N-substituted hydroxyureas as urease inhibitors
Uesato, Shinichi,Hashimoto, Yuichiro,Nishino, Masaru,Nagaoka, Yasuo,Kuwajima, Hiroshi
, p. 1280 - 1282 (2007/10/03)
In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl-(10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme.
