Synthesis of 3-hydroxypyrimidine-2,4-diones. Addition of anilines to benzyloxy isocyanate synthons to give N-hydroxyureas

Article abstract of DOI:10.1055/s-1994-25587

A new method, the addition of N-benzyloxychloroformate to methyl anthranilate followed by base-catalyzed cyclization, has been employed to synthesize the N-hydroxyquinazolinedione 1 and heterocyclic derivatives. N-Benzyloxycarbonylimidazole is a useful sy