Cas 5146-41-8,(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(5-oxo-2,4-diphenyl-imidazolidin-1-yl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

5146-41-8

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Basic information

Product Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(5-oxo-2,4-diphenyl-imidazolidin-1-yl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
Synonyms:
CAS NO:5146-41-8
Molecular Formula:
Molecular Weight: 437.519
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(5-oxo-2,4-diphenyl-imidazolidin-1-yl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(CAS DataBase Reference)
NIST Chemistry Reference: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(5-oxo-2,4-diphenyl-imidazolidin-1-yl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(5146-41-8)
EPA Substance Registry System: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(5-oxo-2,4-diphenyl-imidazolidin-1-yl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(5146-41-8)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 5146-41-8(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 5146-41-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,4 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5146-41:
(6*5)+(5*1)+(4*4)+(3*6)+(2*4)+(1*1)=78
78 % 10 = 8
So 5146-41-8 is a valid CAS Registry Number.

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5146-41-8Relevant academic research and scientific papers

Syntheses and hydrolysis of basic and dibasic ampicillin esters tailored for intracellular accumulation

Paternotte, Isabelle,Fan, Hua Juan,Screve, Pascal,Claesen, Michel,Tulkens, Paul M,Sonveaux, Etienne

, p. 493 - 502 (2001)

Readily hydrolysable basic and dibasic esters of ampicillin were synthesised by alkylation of the carboxylate function of ampicillin to obtain prodrugs that may accumulate in cells and allow for an intracellular delivery of ampicillin (Fan et al., Bioorg. Med. Chem. Lett. 1997, 7, 3107). We found that the β-lactam ring cleavage and the hydrolysis of the ester function were competitive reactions. The prerequisite for biological activity of compounds of this type is therefore that ester hydrolysis proceeds faster than ring opening. Some synthesised compounds show promise as prodrugs since they displayed a reasonable stability and regenerate large quantities of bioactive ampicillin in broth.

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