51478-48-9Relevant academic research and scientific papers
Metal-Free Synthesis of Alkenylazaarenes and 2-Aminoquinolines through Base-Mediated Aerobic Oxidative Dehydrogenation of Benzyl Alcohols
Batra, Sanjay,Dahatonde, Dipak J.,Ghosh, Aritra
, p. 2746 - 2751 (2021)
A metal-free, base-mediated, and atom-efficient oxidative dehydrogenative coupling of substituted phenylmethanols (benzyl alcohols) with methyl azaarenes or phenylacetonitriles to afford substituted alkenylazaarenes or 2-aminoquinolines, respectively is described. CsOH.H2O was discovered to be the base of choice for obtaining optimal yields of the title compounds, although the reaction could proceed with KOH as well. The protocol that works efficiently in the presence of air is amenable over broad range of substrates.
Preparing multi-substituted quinoline type larene and method of pyridine derivatives (by machine translation)
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, (2017/02/09)
The invention discloses a preparing a multi-substituted quinoline type larene and pyridine derivatives. The method comprises the following steps: in the formula II the phenyl tetrazole compounds, alkine compound shown in formula III, alkali, oxidant and catalyst mix, cyclized-denitrification in series of the reaction, the reaction of the compound of the formula I obtained shows. The method has the following characteristics : (1) the economic ; (2) convenient; reaction only needs one-step, one-time feeding and a secondary separation step of the final product can be obtained, because the reaction has a very high chemical selectivity, the separation process is very simple. (3) general ; (4) green. The obtained product is a reaction intermediate in the discharged nitrogen, no other exhaust gas discharge, no pollution to the environment. More importantly, the reaction by-product of aniline nitrogen nitrile base can be used as a new chemical raw materials in other reaction. A high utilization rate of atom of the reaction, no pollution to the environment. (by machine translation)
One-pot synthesis of multisubstituted 2-aminoquinolines from annulation of 1-aryl tetrazoles with internal alkynes via double C-H activation and denitrogenation
Zhang, Lei,Zheng, Liyao,Guo, Biao,Hua, Ruimao
, p. 11541 - 11548 (2015/01/16)
An efficient, one-pot synthesis of multisubstituted 2-aminoquinolines from 1-aryl tetrazoles and internal alkynes has been developed. The reaction involves cyclization of 1-aryl tetrazoles with internal alkynes via rhodium(III)-catalyzed double C-H activa
