514792-62-2

Upstream product

• 100-39-0 benzyl bromide 
• 732246-93-4 (tert-butyl)dimethylsilyl 2-deoxy-2-phthalimido-β-D-glucopyranoside 
• 1203588-91-3 tert-butyldimethylsilyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-2-phthalimido-β-D-glucopyranoside 
• 459170-35-5 tert-butyldimethylsilyl 4,6-O-benzylidene-2-deoxy-2-phthalimido-β-D-glucopyranoside 

Downstream Products

• 732247-03-9 3,6-di-O-benzyl-1-O-tert-butyldimethylsilyl-2-deoxy-4-O-methyl-2-phthalimido-β-D-glucopyranose 
• 1262232-81-4 tert-butyldimethylsilyl 2-O-benzyl-4,6-O-benzylidene-3-O-(2-naphthylmethyl)-β-D-mannopyranosyl-(1>4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside 
• 1203582-46-0 tert-butyldimethylsilyl (4-O-acetyl-2-azido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1→4)-2-deoxy-3,6-di-O-benzyl-2-phthalimido-β-D-glucopyranoside 
• 1203588-92-4 tert-butyldimethylsilyl 2-acetamido-4-O-(4-O-acetyl-2-azido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl)-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranoside 
• 1203588-93-5 tert-butyldimethylsilyl 2-acetamido-4-O-(2-azido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl)-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranoside 
• 1203588-94-6 2-acetamido-4-O-(2-azido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl)-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranose 
• 1169693-68-8 tert-butyldimethylsilyl 4-O-acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalamido-β-D-glucopyranoside 
• 1169693-53-1 tert-butyldimethylsilyl 4,6-O-benzylidene-2-O-levulinoyl-3-O-(2-naphthylmethyl)-β-D-glucopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalamido-β-D-glucopyranoside 

Relevant academic research and scientific papers

Selection of protecting groups and synthesis of a β-1,4-GlcNAc-β- 1,4-GlcN unit

The synthesis of the disaccharide tert-butyldimethylsilyl (4-O-acetyl-2-azido-3,6-di-O-benzyl-2-deoxy-β-d-glucopyranosyl)-3, 6-di-O-benzyl-2-deoxy-2-phthalimido-β-d-glucopyranoside, designed as a repeating unit appearing in oligo- and polysaccharides, whi

Chemical synthesis of UDP-4-O-methyl-GlcNAc, a potential chain terminator of chitin synthesis

Chitin synthase converts uridine diphosphoryl-N-acetylglucosamine (UDP-GlcNAc) to chitin (poly-β-(1→4)-GlcNAc). During polymerization, elongation occurs at the 4-OH (nonreducing) terminus of the growing chitin chain. Blockage of the 4-OH via incorporation of UDP-N-acetyl-4-O- methylglucosamine (UDP-4-OMe-GlcNAc, 3) can potentially terminate chitin polymerization, and represents a novel strategy for chitin synthase inhibition. The chemical synthesis of 3 and preliminary evaluation of its possible incorporation by chitin synthase are reported herein.