514806-53-2

Upstream product

• 1074-82-4 potassium phtalimide 
• 514806-51-0 4-azido-5-bromomethyl-2-phenyl-thiazole 
• 514806-50-9 (4-azido-2-phenyl-thiazol-5-yl)-methanol 
• 115437-26-8 4-azido-5-formyl-2-phenylthiazole 

Downstream Products

• 514806-52-1 C-(4-azido-2-phenyl-thiazol-5-yl)-methylamine 

Relevant academic research and scientific papers

New applications of the imine-ketenimine intramolecular [2+2] cycloaddition reaction: Highly stereocontrolled synthesis of azeto[1,2-a]pyrimidines

Imino-ketenimines 7, in which the reactive functionalities are linked by an allylic tether connecting the imino and ketenimino nitrogen atoms, undergo a formal intramolecular [2+2] cycloaddition to yield azeto[1,2-a]pyrimidines 8. When enantiotopic ketenimine and imine fragments are combined, the resulting azeto[1,2-a]pyrimidines 8e-i contain two stereogenic carbon atoms C-6 and C-7, and the cycloaddition takes place with complete diastereoselectivity in favor of the cis diastereoisomers. This methodology has also been applied to the preparation of some azeto[1,2-a][1,3]thiazolo[4,5-d]pyrimidines 16, representative examples of a new fused heterocyclic system. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002.