51483-84-2

Upstream product

• 111-50-2 Adipic acid dichloride 
• 52321-06-9 cis-1-benzylpyrrolidine-2,5-dicarboxylic acid diethyl ester 
• 29548-86-5 2,5-dibromohexanedioyl dichloride 
• 52321-07-0 cis-1-Benzyl-2,5-pyrrolidinedicarboxylic Acid 

Relevant academic research and scientific papers

3,8-Diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias

There is provided compounds of formula (I), wherein R1, R2 and Ra to Rb have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and v

Synthesis and Structure-Activity Relationship of Di-(3,8-diazabicyclo[3.2.1]octane) Diquaternary Ammonium Salts as Unique Analgesics

Based on the structure characteristics of the lead compounds, 1,1′2-octanedioyl-4,4′-dimethyl-4,4′-dibenzyl dipiperazinium dibromide (2) and 3,8-disubstituted-3,8-diazabicyclo[3.2.1]octanes (DBO), di-(3,8-diazabicyclo[3.2.1]octane) diquaternary ammonium salts 3 a-c were designed and synthesized through a highly practical procedure. Target compounds 3 a-c and the hydrochloride salts of their precursors 10 a-c were evaluated for their in vivo analgesic and sedative activities. Interestingly, the introduction of an endoethylenic bridge in the piperazine of lead compound 2 causes loss of the analgesic activity and increases the toxicity dramatically. This result shows that the flexible conformation of piperazine in compound 2 is favorable for interaction with the receptor, and the quaternization of compounds 10 a-c is the main reason for the toxicity increase.