52321-06-9

Basic information

• Product Name: diethyl 1-benzylpyrrolidine-2,5-dicarboxylate
• Synonyms: Nsc143948;(2S,5R)-Diethyl 1-benzylpyrrolidine-2,5-dicarboxylate
• CAS NO: 52321-06-9
• Molecular Formula: C₁₇H₂₃NO₄
• Molecular Weight: 305.37
• Mol File: 52321-06-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 123-125 °C
• Boiling Point: 145-148 °C(Press: 0.3 Torr)
• Appearance: /
• Density: 1.146±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.83±0.60(Predicted)
• CAS DataBase Reference: diethyl 1-benzylpyrrolidine-2,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 1-benzylpyrrolidine-2,5-dicarboxylate(52321-06-9)
• EPA Substance Registry System: diethyl 1-benzylpyrrolidine-2,5-dicarboxylate(52321-06-9)

Safety Data

• Hazardous Substances Data: 52321-06-9(Hazardous Substances Data)

Usage

General Description

Diethyl 1-benzylpyrrolidine-2,5-dicarboxylate, also known as benzylpyrrolidine dicarboxylate, is a chemical compound with a complex molecular structure. It belongs to the class of pyrrolidine derivatives and is commonly used as a pharmaceutical intermediate in the synthesis of various drugs. diethyl 1-benzylpyrrolidine-2,5-dicarboxylate has been found to have potential biological activities, such as anticonvulsant and anti-inflammatory properties, making it a valuable building block for the development of new medications. Additionally, it has been studied for its potential use as an analgesic and anesthetic agent. However, due to its complex structure and synthetic nature, it requires careful handling and proper storage to ensure its stability and safety. Overall, diethyl 1-benzylpyrrolidine-2,5-dicarboxylate is a versatile chemical compound with various potential applications in the pharmaceutical industry.

Upstream product

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• 137300-49-3 (2R,5S)-2,5-Dibromo-hexanedioyl dichloride 
• 111-50-2 Adipic acid dichloride 
• 124-04-9 Adipic acid 
• 90290-04-3 trans-N-benzyl-2,5-bis(ethoxycarbonyl)pyrrolidine 

Downstream Products

• 90290-04-3 trans-N-benzyl-2,5-bis(ethoxycarbonyl)pyrrolidine 
• 93713-33-8 rac-trans-1-Benzyl-2,5-dicarboxypyrrolidine 
• 52321-07-0 (2S,5S)-1-Benzylpyrrolidine-2,5-dicarboxylic acid 
• 191850-97-2 cis-1-benzyl 2,5-bis(hydroxymethyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Streamlined Synthesis of a Bicyclic Amine Moiety Using an Enzymatic Amidation and Identification of a Novel Solid Form

We describe a series of improvements to the synthesis of a 3,8-diazabicyclo[3.2.1]octane derivative that result in a reduced step count and higher overall efficiency compared to previously published syntheses. Our method includes optimization and mechanistic understanding of a key diastereoselective cyclization to achieve a >95:5 diastereomeric ratio, as well as demonstration of a unique enzyme-catalyzed amidation reaction using hexamethyldisilazane as both an ammonia source and scavenger. Finally, we identify a novel cocrystal solid form of the target compound that provides improved purity and material properties. Demonstration of the new chemistry to prepare >100 kg of the target compound serves to illustrate the robustness of the new process.

Synthesis of bridged bicyclic amino alcohols as compact modules for medicinal chemistry

The efficient synthetic routes of three bridged bicyclic amino alcohols were reported. It is conceivable that these compounds could be readily used as compact modules in medicinal chemistry to fine-tune physicochemical and pharmacokinetic properties, in order to eventually improve the overall quality of small molecule drug candidates.

Pyruvate kinase activators for use in therapy

Described herein are methods for using compounds that activate pyruvate kinase.