514844-41-8Relevant academic research and scientific papers
Dipeptide analogs for treating conditions associated with amyloid fibril formation
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Page/Page column 40-41, (2015/09/22)
Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipeptide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.
New active series of growth hormone secretagogues
Guerlavais, Vincent,Boeglin, Damien,Mousseaux, Delphine,Oiry, Catherine,Heitz, Annie,Deghenghi, Romano,Locatelli, Vittorio,Torsello, Antonio,Ghé, Corrado,Catapano, Filomena,Muccioli, Giampiero,Galleyrand, Jean-Claude,Fehrentz, Jean-Alain,Martinez, Jean
, p. 1191 - 1203 (2007/10/03)
New growth hormone secretagogue (GHS) analogues were synthesized and evaluated for growth hormone releasing activity. This series derived from EP-51389 is based on a gem-diamino structure. Compounds that exhibited higher in vivo GH-releasing potency than hexarelin in rat (subcutaneous administration) were then tested per os in beagle dogs and for their binding affinity to human pituitary GHS receptors and to hGHS-R 1a. Compound 7 (JMV 1843, H-Aib-(D)-Trp-(D)-gTrp-formyl) showed high potency in these tests and was selected for clinical studies.
