51488-87-0

Upstream product

• 2401-24-3 2-chloro-5-methoxyaniline 
• 108-24-7 acetic anhydride 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 588-16-9 m-methoxyacetanilide 

Downstream Products

• 1075748-40-1 3-chloro-6-methoxybenzene-1,2-diamine 
• 1075748-38-7 6-chloro-3-methoxy-2-nitrophenylamine 
• 1075748-39-8 N-(6-chloro-3-methoxy-2-nitrophenyl)acetamide 
• 59442-40-9 N-(2-chloro-5-methoxy-4-nitrophenyl)acetamide 
• 161362-76-1 1-(4-acetylamino-5-chloro-2-hydroxyphenyl)-5-chloropentan-1-one 
• 188193-11-5 4-bromo-2-chloro-5-methoxyacetanilide 

Relevant academic research and scientific papers

NEAR-INFRARED NERVE-SPARING FLUOROPHORES

Provided are far red to near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.

NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION

Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.

Selective Halogenation Using an Aniline Catalyst

Electrophilic halogenation is used to produce a wide variety of halogenated compounds. Previously reported methods have been developed mainly using a reagent-based approach. Unfortunately, a suitable "catalytic" process for halogen transfer reactions has yet to be achieved. In this study, arylamines have been found to generate an N-halo arylamine intermediate, which acts as a highly reactive but selective catalytic electrophilic halogen source. A wide variety of heteroaromatic and aromatic compounds are halogenated using commercially available N-halosuccinimides, for example, NCS, NBS, and NIS, with good to excellent yields and with very high selectivity. In the case of unactivated double bonds, allylic chlorides are obtained under chlorination conditions, whereas bromocyclization occurs for polyolefin. The reactivity of the catalyst can be tuned by varying the electronic properties of the arene moiety of catalyst.

Highly selective C-H functionalization/halogenation of acetanilide

Highly regioselective C-H functionalization/halogenation of acetanilides to produce ortho-haloacetanilides was catalyzed by Pd(OAc)2 and Cu(OAc)2 with CuX2 as the halogen source. Copyright