5149-69-9

Usage

Chemical Properties

Brown solid

Safety Profile

Poison by intraperitoneal route.Moderately toxic by ingestion. Whenheated to decomposition it emits toxic fumes of CN- andNOx.

InChI:InChI=1/C11H7NO2/c12-6-5-9(13)11-7-8-3-1-2-4-10(8)14-11/h1-4,7H,5H2

Upstream product

• 23489-36-3 1-(benzofuran-2-yl)-2-bromoethan-1-one 
• 1646-27-1 methyl benzofuran-2-carboxylate 
• 75-05-8 acetonitrile 
• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 

Downstream Products

• 1173187-68-2 2-benzofuran-2-oyl-3-(phenylamino)-3-thioxopropanenitrile 
• 1296726-75-4 5-(1-benzofuran-2-yl)-4-cyano-2,2-diphenyl-2,3-dihydrofuran-3-carboxamide 
• 1323989-07-6 2-(benzofuran-2-yl)-4,5-dihydro-5,5-diphenylfuran-3-carbonitrile 
• 1323989-18-9 2-(1-benzofuran-2-yl)-5,5-bis(4-fluorophenyl)-4,5-dihydrofuran-3-carbonitrile 
• 1323989-15-6 2-(1-benzofuran-2-yl)-4,5-dihydro-5-methyl-5-phenylfuran-3-carbonitrile 

Relevant academic research and scientific papers

SeO2-Mediated One-Pot Synthesis of 3-Cyanofurans from 3-Oxo-3-arylpropanenitriles and Substituted Acetaldehydes

An SeO2-mediated one-pot method was established for the synthesis of 3-cyanofurans from 3-oxo-3-arylpropanenitriles and substituted acetaldehydes. The generality of the reaction was explored, and a plausible mechanism is proposed.

Radical cyclizations of conjugated esters and amides with 3-oxopropanenitriles mediated by manganese(III) acetate

Radical cyclizations of conjugated esters and amides with 3-oxopropanenitriles in presence of manganese(III) acetate produced ethyl 4-cyano-2,3-dihydrofuran-3-carboxylates and 4-cyano-2,3-dihydrofuran-3- carboxamides in good yields. The radical cyclizations of conjugated amides gave 2,3-dihydrofurans in better yields than that of conjugated esters. Moreover, the reactions of thienyl substituted amides and esters with 3-oxopropanenitriles afforded 2,3-dihydrofurans more efficiently than phenyl substituted ones. ARKAT-USA, Inc.

Oxidative cyclization of 3-oxopropanenitriles with α,β-unsaturated amides by manganese(III) acetate. Regio- and stereoselective synthesis of 4-cyano-2,3-dihydrofuran-3-carboxamides

4-Cyano-2,3-dihydrofuran-3-carboxamides were obtained from the oxidative cyclization of 3-oxopropanenitriles with unsaturated amides using manganese(III) acetate. Treatment of 3-oxopropanenitriles with (2E)-3-(5-methyl-2-furyl)acrylamide and (2E)-3-(2-thi

Allosteric adenosine receptor modulators

The present invention relates to compounds of formulas (IA) and (IB): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators for uses including protection against hypoxia and isc