51510-01-1

Basic information

• Product Name: 4-(Hydroxymethyl)-4-phenylcyclohexan-1-one
• Synonyms: 4-(Hydroxymethyl)-4-phenylcyclohexan-1-one
• CAS NO: 51510-01-1
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.26494
• Mol File: 51510-01-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(Hydroxymethyl)-4-phenylcyclohexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Hydroxymethyl)-4-phenylcyclohexan-1-one(51510-01-1)
• EPA Substance Registry System: 4-(Hydroxymethyl)-4-phenylcyclohexan-1-one(51510-01-1)

Safety Data

• Hazardous Substances Data: 51510-01-1(Hazardous Substances Data)

Upstream product

• 51510-00-0 (8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)methanol 
• 51509-99-0 8-Phenyl-1,4-dioxaspiro<4.5>decan-8-carbonsaeure 

Relevant articles and documents

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors

The synthesis and SAR of a series of 4,4-disubstituted cyclohexylbenzamide inhibitors of 11β-HSD1 are described. Optimization rapidly led to potent, highly selective, and orally bioavailable inhibitors demonstrating efficacy in both rat and non-human primate ex vivo pharmacodynamic models.

Benzamide derivatives and uses related thereto

Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.

4-Arylcyclohexylamines

The invention relates to novel 4-hydroxymethyl(acyloxymethyl and methyl)-4-arylcyclohexylamines embraced by the formula SPC1 Wherein Ar is an aromatic ring selected from the group consisting of phenyl and naphthyl, each of which has from zero through three substituents independently selected from the group consisting of fluorine, chlorine, bromine, lower alkyl of one through three carbon atoms, lower alkoxy of one through three carbon atoms, and lower alkylthio of one through three carbon atoms; Z is selected from the group consisting of hydrogen, hydroxy and lower acyloxy of one through four carbon atoms; ? is a generic expression denoting cis and trans stereoconfiguration and mixtures thereof, with the proviso that when the stereoconfiguration of the linkage connecting the cyclohexane ring and CH2 Z is cis to the amino group, the linkage connecting the cyclohexane and Ar rings is trans, and vice versa; R1 is selected from the group consisting of hydrogen and lower alkyl of one through three carbon atoms; R2 is selected from the group consisting of hydrogen, lower alkyl of one through three carbon atoms, EQU1 WHEREIN N IS 2 THROUGH 5 AND Ar has the same meaning as above; R1 and R2 taken together with --N is a saturated heterocyclic amino radical selected from the group consisting of unsubstituted and substituted pyrrolidino, piperidino, hexamethylenimino, morpholino and piperazino; and pharmacologically acceptable acid addition salts thereof. It also relates to intermediates and processes for the preparation of the aforesaid novel compounds (I) and novel derivatives thereof. The administration to humans and animals of the novel compounds (I) depresses their central nervous systems and lowers their blood pressures.