51510-00-0

Upstream product

• 51509-98-9 8-Phenyl-1,4-dioxaspiro<4.5>decan-8-carbonitril 
• 56327-24-3 8-phenyl-1,4-dioxaspiro[4,5]decane-8-carboxaldehyde 
• 25115-74-6 4-cyano-4-phenylcyclohexanone 

Downstream Products

• 374819-20-2 (1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methyl 3,5-bis(trifluoromethyl)benzoate 
• 51510-01-1 4-(hydroxymethyl)-4-phenylcyclohexanone 
• 374819-24-6 (RS)-1-{1-[(4-oxo-1-phenylcyclohexyl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene 
• 374819-21-3 (4-oxo-1-phenylcyclohexyl}methyl 3,5-bis(trifluoromethyl)benzoate 
• 374819-26-8 (RS)-β-[(4-oxo-1-phenylcyclohexyl)methoxy]-3,5-bis(trifluoromethyl)benzeneethanol 
• 374819-23-5 (RS)-1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethyl}-3,5-bis(trifluoromethyl)benzene 
• 374819-22-4 1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethenyl}-3,5-bis(trifluoromethyl)benzene 
• 374819-25-7 (RS)-β-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]-3,5-bis(trifluoromethyl) benzeneethanol 
• 51510-02-2 4-acetoxymethyl-4-phenylcyclohexanone 
• 919100-03-1 8-phenyl-1,4-dioxaspiro[4.5]decane-8-methyl methanesulfonate 
• 374819-12-2 1-{[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]methyl}-2-methoxybenzene 
• 1429045-51-1 4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylcyclohexanol 
• 1429045-52-2 1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene 
• 1429045-55-5 C₂₂H₂₁F₆NO₂ 

Relevant academic research and scientific papers

Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression

This report describes the synthesis, structure-activity relationships and activity of piperidine, homopiperidine, and azocane derivatives combining NK1 receptor (NK1R) antagonism and serotonin reuptake transporter (SERT) inhibition. Our studies culminated in the discovery of piperidine 2 and homopiperidine 8 as potent dual NK1R antagonists-SERT inhibitors. Compound 2 demonstrated significant activity in the gerbil forced swimming test, suggesting that dual NK1R antagonists-SERT inhibitors may be useful in treating depression disorders.

4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists I.

A series of novel 4,4-disubstituted cyclohexylamine based NK(1) antagonists is described. The effect of changes to the C(1)-C(4) relative stereochemistry on the cyclohexane ring and replacements for the flexible linker are discussed, leading to the identification of compounds with high affinity and good in vivo duration of action.