515142-62-8

Upstream product

• 91076-93-6 methyl 3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 852329-26-1 C₂₁H₂₂N₃O₃SCl 
• 1197420-11-3 6-(4-chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]-pyrimidin-4(3H)-one 
• 1348299-80-8 6-(4-chlorophenyl)-3-(4-((4-hydroxytetrahydro-2H-pyran-4-yl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1346773-75-8 6-(4-chlorophenyl)-3-(4-((1-hydroxycyclopentyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1347638-66-7 6-(4-chlorophenyl)-3-(4-((1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1349720-93-9 6-(4-chlorophenyl)-3-(4-((3-hydroxyoxetan-3-yl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1197420-12-4 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl dihydrogen phosphate 
• 1197420-29-3 dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate 
• 1239489-42-9 C₃₁H₃₀ClF₂N₃O₇S 
• 1197420-13-5 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate 

Relevant academic research and scientific papers

Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists

A series of thienopyrimidinone bis-aminopyrrolidine ureas were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor-1. These compounds exhibit potent binding affinity (Ki = 3 nM) and good in vitro metabolic stability.

NOVEL AZACYCLY-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

The invention relates to azacyclyl-substituted arylthienopyrimidinones and their derivatives of formula (I), and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the azacyclyl-substituted aryithienopyrimidinones of the invention and their derivatives as MCH antagonists.

NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

The invention relates to amino alcohol-substituted arylthienopyrimidinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one amino alcohol-su