515171-00-3Relevant academic research and scientific papers
Pharmacophore-based small molecule CXCR4 ligands
Narumi, Tetsuo,Tanaka, Tomohiro,Hashimoto, Chie,Nomura, Wataru,Aikawa, Haruo,Sohma, Akira,Itotani, Kyoko,Kawamata, Miyako,Murakami, Tsutomu,Yamamoto, Naoki,Tamamura, Hirokazu
scheme or table, p. 4169 - 4172 (2012/07/03)
Low molecular weight CXCR4 ligands were developed based on the peptide T140, which has previously been identified as a potent CXCR4 antagonist. Some compounds with naphthyl, fluorobenzyl and pyridyl moieties as pharmacophore groups in the molecule showed significant CXCR4-binding activity and anti-HIV activity. Structure-activity relationships were studied and characteristics of each of these three moieties necessary for CXCR4 binding were defined. In this way, CXCR4 ligands with two types of recognition modes for CXCR4 have been found.
Alkyne matrix metalloproteinase inhibitors
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, (2008/06/13)
A compound of Formula I or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibitors of MMP-13. The compounds are useful for treating diseases mediated by MMP-13, including cancer and arthritis.
