107045-28-3

Basic information

• Product Name: tert-butyl 4-(aMinoMethyl)benzoate
• Synonyms: tert-butyl 4-(aMinoMethyl)benzoate;4-(aMinoMethyl)benzoic acid tert-butyl ester
• CAS NO: 107045-28-3
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.26888
• EINECS: -0
• Mol File: 107045-28-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 311.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.052±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.66±0.10(Predicted)
• CAS DataBase Reference: tert-butyl 4-(aMinoMethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(aMinoMethyl)benzoate(107045-28-3)
• EPA Substance Registry System: tert-butyl 4-(aMinoMethyl)benzoate(107045-28-3)

Safety Data

• Hazardous Substances Data: 107045-28-3(Hazardous Substances Data)

Usage

Description

Tert-butyl 4-(aminomethyl)benzoate is an organic compound that serves as an intermediate in the synthesis of benzimidazoles and their analogs. It is characterized by its ability to form a stable amide bond with carboxylic acids, which makes it a valuable building block in organic chemistry.

Uses

Used in Pharmaceutical Industry:
Tert-butyl 4-(aminomethyl)benzoate is used as a reactant in the preparation of benzimidazoles and their analogs for their application as protein kinase inhibitors. These inhibitors play a crucial role in the development of drugs targeting various diseases, including cancer and inflammatory conditions, by modulating the activity of specific protein kinases involved in disease progression.
Used in Organic Chemistry:
In the field of organic chemistry, tert-butyl 4-(aminomethyl)benzoate is utilized as a versatile building block for the synthesis of various complex organic molecules. Its ability to form stable amide bonds with carboxylic acids allows for the creation of a wide range of compounds with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 121579-86-0 4-chloromethylbenzoic acid tert-butyl ester 
• 619-65-8 4-cyanobenzoic Acid 
• 55696-50-9 tert-butyl 4-cyanobenzoate 
• 58933-52-1 4-((benzyloxycarbonylamino)methyl)benzoic acid 
• 56-91-7 p-aminomethylbenzoic acid 
• 220851-46-7 4-(benzyloxycarbonylaminomethyl)benzoic acid tert-butyl ester 

Downstream Products

• 658082-28-1 4-[(5-bromo-2-iodobenzoylamino)-methyl]benzoic acid tert-butyl ester 
• 1202709-56-5 4-(methanesulfonylaminomethyl)benzoic acid tert-butyl ester 
• 1332857-20-1 4-{4'-[2-(2'''-chloroethyl)-1,2,4-thiadiazolidine-3,5-dionyl]} sodium benzoate 
• 1332857-19-8 C₁₃H₁₅NO₂S 
• 1346771-59-2 C₁₆H₁₉ClN₂O₄S 
• 1332925-73-1 C₁₂H₁₁ClN₂O₄S 
• 261789-05-3 4-chloro-1,8-naphthalic anhydride tert-butyl methyl benzoate 

Relevant articles and documents

BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5

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Preparation method of Na molecular fluorescent intermediate and preparation method of Na molecular fluorescent sensor

The invention provides a preparation method of a Na molecular fluorescent intermediate and a preparation method of a Na molecular fluorescent sensor. The Na molecular fluorescent intermediatehas a structure as shown in a formula I. The preparation method of the Na molecular fluorescent intermediate comprises the following steps: S1, carrying out a substitution reaction on o-anisidineand alpha-methyl haloacetate to obtain a compound 2; S2, carrying out a reduction reaction on the compound 2 to obtain a compound 3; S3, carrying out a hydroxyl substitution on the compound 4 by adopting toluene sulfonyl chloride to obtain a compound 5, wherein the compound 4 has a structural formula as the follows; S4, carrying out a cyclization reaction on the compound 3 and the compound 5 to obtain a compound 6; S5, carrying out a formylation reaction on the compound 6 to obtain a compound 7; S6, carrying out a henry reaction on the compound 7 with nitromethane to obtain a compound 8; and S7, carrying out nitroso reduction reaction on the compound 8 to obtain the Na molecular fluorescent intermediate. The method is beneficial to improving the yield of the Na molecular fluorescentintermediate.