51523-79-6

Basic information

• Product Name: 2,4-Difluorophenylhydrazine hydrochloride
• Synonyms: BIO-FARMA BF000363;2,4-DIFLUOROHYDRAZINOBENZENE HYDROCHLORIDE;2,4-DIFLUOROPHENYL HYDRAZINE HCL;2,4-DIFLUOROPHENYLHYDRAZINE HYDROCHLORIDE;1-(2,4-DIFLUOROPHENYL)HYDRAZINE HYDROCHLORIDE;TIMTEC-BB SBB003743;2,4-DifluorophenilHidrazine*Hcl;2,4-Difluorophenylhydrazine hydrochloride 97%
• CAS NO: 51523-79-6
• Molecular Formula: C₆H₆F₂N₂*ClH
• Molecular Weight: 180.58
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Phenylhydrazine;Phenyls & Phenyl-Het;Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 51523-79-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 210 °C (dec.)(lit.)
• Boiling Point: 185.1 °C at 760 mmHg
• Flash Point: 65.7 °C
• Appearance: white to light yellow crystal powder
• Density: 1.379g/cm3
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• BRN: 5411448
• CAS DataBase Reference: 2,4-Difluorophenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluorophenylhydrazine hydrochloride(51523-79-6)
• EPA Substance Registry System: 2,4-Difluorophenylhydrazine hydrochloride(51523-79-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37-36/37/39-22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 51523-79-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 617-35-6 2-oxo-propionic acid ethyl ester 

Downstream Products

• 910579-48-5 3-(2,4-difluorophenylhydrazino)-5,5-dimethylcyclohex-2-en-1-one 
• 251443-49-9 1-(2,4-difluorophenyl)-4,5-dihydro-5-(4-methylsulphonylphenyl)-3-trifluoromethyl-1H-pyrazole 
• 308248-95-5 1-(2,4-difluorophenyl)-6,6-dimethyl-4,5-dioxo-4,5,6,7-tetrahydroindazole 
• 308248-90-0 1-(2,4-difluorophenyl)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazole 
• 797053-63-5 [1-(2,4-difluoro-phenyl)-5-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-phenyl-methanol 
• 797053-69-1 [1-(2,4-difluoro-phenyl)-5-phenyl-1H-pyrazol-4-yl]-phenyl-methanol 
• 797053-40-8 [1-(2,4-difluoro-phenyl)-5-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-methanol 
• 797053-51-1 1-(2,4-difluoro-phenyl)-5-(4-fluoro-phenyl)-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

Design, Synthesis, and Antifungal Activity of 2,6-Dimethyl-4-aminopyrimidine Hydrazones as PDHc-E1 Inhibitors with a Novel Binding Mode

A series of novel 2,6-dimethyl-4-aminopyrimidine hydrazones 5 were rationally designed and synthesized as pyruvate dehydrogenase complex E1 (PDHc-E1) inhibitors. Compounds 5 strongly inhibited Escherichia coli (E. coli) PDHc-E1 (IC50 values 0.94-15.80 μM). As revealed by molecular docking, site-directed mutagenesis, enzymatic, and inhibition kinetic analyses, compounds 5 competitively inhibited PDHc-E1 and bound in a "straight"pattern at the E. coli PDHc-E1 active site, which is a new binding mode. In in vitro antifungal assays, most compounds 5 at 50 μg/mL showed more than 80% inhibition against the mycelial growth of six tested phytopathogenic fungi, including Botrytis cinerea, Monilia fructigena, Colletotrichum gloeosporioides, andBotryosphaeria dothidea. Notably, 5f and 5i were 1.8-380 fold more potent against M. fructigena than the commercial fungicides captan and chlorothalonil. In vivo, 5f and 5i controlled the growth of M. fructigena comparably to the commercial fungicide tebuconazole. Thus, 5f and 5i have potential commercial value for the control of peach brown rot caused by M. fructigena.

New Heterocyclic compounds for therapeutic use

A class of compounds particularly diaryl pyrazole of general formulas 1 and 2 where R and R′ represents alkyl, hydrogen, halogens, haloalkyl, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, hydroxyalkyl, alkylthio, alkylsulfinyl, alkylsulphonyl, N- alkylsulfamyl, N-arylsulfamyl, cyanoamido, amino, amidino, N-monoalkylamido, N-monoarylamido, N,N-dialkylamido, N-alkyl-N-arylamido, N, N-dialkylsulfamyl with the alkyl, or alkyl part of each such group containing 1-3 carbon atoms or mixtures thereof optionally their salts when they exist, and preparation thereof. The compounds of the present invention are antiinflammatory, antipyretic, antirheumatic, antiosteoarthritic agents with antibacterial activity. The particular class of compounds is given below (Formula 1 and Formula 2).