51524-84-6

Usage

Purification Methods

Crystallise the acid from H2O (needles), pet ether (plates) or CHCl3 (m 127o). The hydrochloride has m 244o (plates from EtOH). [Beilstein 14 H 391, 14 I 559.]

InChI:InChI=1/C8H9NO2/c1-9-7-4-2-3-6(5-7)8(10)11/h2-5,9H,1H3,(H,10,11)

Upstream product

• 25593-07-1 3-(methyl-nitroso-amino)-benzoic acid 
• 7732-18-5 water 
• 17264-94-7 sodium m-aminobenzoate 
• 77-78-1 dimethyl sulfate 
• 66-27-3 Methyl methanesulfonate 
• 99-05-8 meta-aminobenzoic acid 
• 82957-07-1 3-Guanidinobenzoic acid 
• 104542-38-3 methyl 3-(methylamino)benzoate 

Downstream Products

• 875769-16-7 3-[N-(2,4-dinitro-5-fluorophenyl)-N-methylamino]benzoic acid 
• 1438087-95-6 (1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-yl 3-((tert-butoxycarbonyl)(methyl)amino)benzoate 
• 168162-30-9 3-(N-tert-butoxycarbonyl-N-methyl-amino)-benzoic acid 
• 1438088-34-6 (1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-yl 3-(methylamino)benzoate 
• 192632-34-1 ethyl 3-(methylamino)benzoate 
• 1246636-56-5 3-(N-((2,4-diaminopteridin-6-yl)methyl)-N-methylamino)benzoic acid 
• 875769-14-5 C₁₆H₁₆N₆⁽¹⁺⁾O₈^(1-) 
• 104542-38-3 methyl 3-(methylamino)benzoate 

Relevant academic research and scientific papers

Infrared spectra and molecular structure. Part II. N-methyl- and N, N-dimethylaminobenzoic acids

Infrared spectra of N-methyl- and N,N-dimethylaminobenzoic acids have been investigated. All the acids except N,N-dimethylanthranilic acid showed neutral structures in the solid state. The N,N-dimethylanthranilic acid, however, exhibited a dipolar structure with strong intramolecular hydrogen bonding in the solid state while in solution it is neutral.

PABA/NO as an anticancer lead: Analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity

PABA/NO is a diazeniumdiolate of structure Me2NN(O)=NOAr (where Ar is a 5-substituted-2,4-dinitrophenyl ring whose 5-substituent is N-methyl-p-aminobenzoic acid). It has shown activity against human ovarian cancer xenografts in mice rivaling th

4-HYDROXPIPERIDINE DERIVATIVE WITH ANALGETIC ACTIVITY

A compound represented by the following Formula (I): (wherein A represents oxygen atom or -NR3- (R3 represents hydrogen atom or lower alkyl group); R1 represents nitro group, lower alkoxycarbonyl group, carbamoyl group unsubstituted or mono- or di-substituted by lower alkyl group, unprotected or protected hydroxyl group, unprotected or protected carboxyl group, lower alkyl group substituted by unprotected or protected hydroxyl group, or tetrazolyl group; and R2 represents hydrogen atom, cyano group or lower alkylsulfonyl group, provided that when A is - NR3-, it is excluded that R1 represents unprotected or protected hydroxyl group or lower alkyl group substituted by unprotected or protected hydroxyl group) or its salt, and method for producing the compound, and a pharmaceutical composition containing the compound as active ingredient.

3-(substituted phenyl)phthalides

Process comprises the combination of the three steps of condensing 3-N(R)2 -4-X-benzoic acid with an aromatic or heterocyclic aldehyde, Y-CHO, under acidic conditions to produce 3-Y-5-X-6-N(R)2 phthalide (II), condensing said phthalide with a compound of the formula Z-H under alkaline or acid conditions to produce 2-(α-Y-α-Z)methyl-4-X-5-N(R)2 benzoic acid (III), and oxidizing said benzoic acid to produce 3-Y-3-Z-5-X-6-N(R)2 phthalide (I) where: R is hydrogen, non-tertiary alkyl of one to four carbon atoms, benzyl or substituted benzyl; X is hydrogen or halo; Y is 4-R1 -3-R2 -2-R1 -phenyl, 1-R5 -2-R6 -5/6-R4 -3-indolyl, 9-R7 -3-carbazolyl, 9-julolidinyl, 3,4-dioxymethylenephenyl, 2-thienyl, 1-R8 -2-pyrrolyl, or 4-pyridinyl; and Z is 4-R1 -3-R2 -2-R1 -phenyl, 1-R5 -2-R6 -5/6-R4 -3-indolyl or 1-R8 -2-pyrrolyl which are useful as colorless precursor color formers in carbonless duplicating and in thermal marking systems. The intermediates, 3-Y-5-X-6-N(R)2 phthalides (II) and 2-(α-Y-α-Z)methyl-4-X-5-N(R)2 benzoic acids (III) also have utility as colorless precursor color formers in carbonless duplicating and thermal marking systems.