51524-84-6

Basic information

• Product Name: 3-METHYLAMINO-BENZOIC ACID
• Synonyms: 3-METHYLAMINO-BENZOIC ACID;Benzoic acid, 3-(methylamino)- (9CI);3-(MethylaMino)benzoic acid HCl;3-(MethylaMino)benzoic acid 97%
• CAS NO: 51524-84-6
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16
• Product Categories: CARBOXYLICACID;Aromatic Amino AcidsCarbonyl Compounds;C8;Carboxylic Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 51524-84-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 122-126 °C
• Boiling Point: 273.17°C (rough estimate)
• Flash Point: 158.2oC
• Appearance: /
• Density: 1.2023 (rough estimate)
• Vapor Pressure: 3.95E-05mmHg at 25°C
• Refractive Index: 1.5810 (estimate)
• Storage Temp.: 2-8°C
• PKA: 5.10(at 25℃)
• CAS DataBase Reference: 3-METHYLAMINO-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLAMINO-BENZOIC ACID(51524-84-6)
• EPA Substance Registry System: 3-METHYLAMINO-BENZOIC ACID(51524-84-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 51524-84-6(Hazardous Substances Data)

Usage

Purification Methods

Crystallise the acid from H2O (needles), pet ether (plates) or CHCl3 (m 127o). The hydrochloride has m 244o (plates from EtOH). [Beilstein 14 H 391, 14 I 559.]

InChI:InChI=1/C8H9NO2/c1-9-7-4-2-3-6(5-7)8(10)11/h2-5,9H,1H3,(H,10,11)

Upstream product

• 104542-38-3 methyl 3-(methylamino)benzoate 
• 99-05-8 meta-aminobenzoic acid 
• 82957-07-1 3-Guanidinobenzoic acid 
• 66-27-3 Methyl methanesulfonate 
• 7732-18-5 water 
• 17264-94-7 sodium m-aminobenzoate 
• 77-78-1 dimethyl sulfate 
• 25593-07-1 3-(methyl-nitroso-amino)-benzoic acid 

Downstream Products

• 875769-16-7 3-[N-(2,4-dinitro-5-fluorophenyl)-N-methylamino]benzoic acid 
• 1438087-95-6 (1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-yl 3-((tert-butoxycarbonyl)(methyl)amino)benzoate 
• 168162-30-9 3-(N-tert-butoxycarbonyl-N-methyl-amino)-benzoic acid 
• 1438088-34-6 (1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-yl 3-(methylamino)benzoate 
• 104542-38-3 methyl 3-(methylamino)benzoate 
• 192632-34-1 ethyl 3-(methylamino)benzoate 
• 1246636-56-5 3-(N-((2,4-diaminopteridin-6-yl)methyl)-N-methylamino)benzoic acid 
• 875769-14-5 C₁₆H₁₆N₆⁽¹⁺⁾O₈^(1-) 

Relevant articles and documents

Infrared spectra and molecular structure. Part II. N-methyl- and N, N-dimethylaminobenzoic acids

Infrared spectra of N-methyl- and N,N-dimethylaminobenzoic acids have been investigated. All the acids except N,N-dimethylanthranilic acid showed neutral structures in the solid state. The N,N-dimethylanthranilic acid, however, exhibited a dipolar structure with strong intramolecular hydrogen bonding in the solid state while in solution it is neutral.

4-HYDROXPIPERIDINE DERIVATIVE WITH ANALGETIC ACTIVITY

A compound represented by the following Formula (I): (wherein A represents oxygen atom or -NR3- (R3 represents hydrogen atom or lower alkyl group); R1 represents nitro group, lower alkoxycarbonyl group, carbamoyl group unsubstituted or mono- or di-substituted by lower alkyl group, unprotected or protected hydroxyl group, unprotected or protected carboxyl group, lower alkyl group substituted by unprotected or protected hydroxyl group, or tetrazolyl group; and R2 represents hydrogen atom, cyano group or lower alkylsulfonyl group, provided that when A is - NR3-, it is excluded that R1 represents unprotected or protected hydroxyl group or lower alkyl group substituted by unprotected or protected hydroxyl group) or its salt, and method for producing the compound, and a pharmaceutical composition containing the compound as active ingredient.