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66-27-3

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66-27-3 Usage

Description

Methyl methanesulfonate, also known as MMS, is a chemical compound with the formula CH3SO2OCH3. It is a colorless liquid with a strong, irritating odor. Methyl methanesulfonate is a potent alkylating agent that can form DNA adducts by adding methyl groups to specific sites on DNA bases, leading to mutations and other adverse effects.

Uses

Used in Chemical Research:
Methyl methanesulfonate is used as a mutagen and teratogen in experimental studies to investigate the mechanisms of DNA damage, repair, and mutagenesis. It is commonly employed in laboratory settings to induce genetic mutations in various organisms, including bacteria, yeast, and mammalian cells, to study the effects of DNA damage on cellular processes and to develop new strategies for DNA repair and mutagenesis prevention.
Used in Toxicology and Carcinogenesis Studies:
Methyl methanesulfonate is used as a brain carcinogen in toxicology and carcinogenesis research to study the effects of DNA alkylation on the development of brain tumors and to investigate the mechanisms of chemical-induced carcinogenesis. This helps researchers to better understand the molecular basis of cancer development and to identify potential therapeutic targets for the prevention and treatment of brain tumors.
Used in Environmental Monitoring:
Methyl methanesulfonate can be used as an environmental pollutant indicator in monitoring studies to assess the presence of hazardous chemicals in air, water, and soil samples. The detection of MMS in environmental samples can provide valuable information on the sources, distribution, and potential health risks associated with exposure to alkylating agents.
Used in Pharmaceutical Development:
Methyl methanesulfonate can be used as a tool compound in the development of new drugs and therapies targeting DNA repair mechanisms and cancer treatment. By studying the effects of MMS on DNA and cellular processes, researchers can gain insights into the molecular pathways involved in DNA damage response and develop new strategies for the prevention and treatment of cancer and other diseases associated with DNA damage.

Air & Water Reactions

Water soluble.

Reactivity Profile

Methyl methanesulfonate is incompatible with strong oxidizing agents, strong acids and strong bases.

Fire Hazard

Methyl methanesulfonate is combustible.

Safety Profile

Confirmed carcinogen with carcinogenic and neoplastigenic data. Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human mutation data reported. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of SOx.

Potential Exposure

Research chemical and cancer drug. No longer produced commercially in the United States.

Carcinogenicity

Methyl methanesulfonate is reascarcinogen based on sufficient evi onably anticipated to be a human dence of carcinogenicity from studies in experimental animals.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Purify the ester by careful fractionation and collecting the middle fraction. Suspected CARCINOGEN. Note that MeSO3H has b 167-167.5o/10mm and methanesulfonic anhydride has b 138o/10mm)—both are possible impurities. [Beilstein 4 IV 11.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of lab chemicals or expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Check Digit Verification of cas no

The CAS Registry Mumber 66-27-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 66-27:
(4*6)+(3*6)+(2*2)+(1*7)=53
53 % 10 = 3
So 66-27-3 is a valid CAS Registry Number.
InChI:InChI=1/C2H6O3S/c1-5-6(2,3)4/h1-2H3

66-27-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (M0369)  Methyl Methanesulfonate  >98.0%(GC)

  • 66-27-3

  • 25g

  • 995.00CNY

  • Detail
  • Alfa Aesar

  • (H55120)  Methyl methanesulfonate, 99%   

  • 66-27-3

  • 5g

  • 319.0CNY

  • Detail
  • Alfa Aesar

  • (H55120)  Methyl methanesulfonate, 99%   

  • 66-27-3

  • 25g

  • 992.0CNY

  • Detail
  • Alfa Aesar

  • (H55120)  Methyl methanesulfonate, 99%   

  • 66-27-3

  • 100g

  • 3064.0CNY

  • Detail
  • Sigma-Aldrich

  • (78697)  Methylmethanesulfonate  certified reference material, TraceCERT®

  • 66-27-3

  • 78697-120MG

  • 1,054.17CNY

  • Detail
  • Aldrich

  • (129925)  Methylmethanesulfonate  99%

  • 66-27-3

  • 129925-5G

  • 504.27CNY

  • Detail
  • Aldrich

  • (129925)  Methylmethanesulfonate  99%

  • 66-27-3

  • 129925-25G

  • 1,359.54CNY

  • Detail
  • Aldrich

  • (129925)  Methylmethanesulfonate  99%

  • 66-27-3

  • 129925-100G

  • 5,465.07CNY

  • Detail

66-27-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl methanesulfonate

1.2 Other means of identification

Product number -
Other names Methanesulfonic acid,methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66-27-3 SDS

66-27-3Relevant articles and documents

King et al.

, p. 6304 (1971)

METHOD FOR THE PRODUCTION OF ALKANE SULFONIC ACID AT NON-SUPERACIDIC CONDITIONS

-

Page/Page column 12, (2020/10/09)

The present invention refers to a method for the production of alkane sulfonic acid, in which SO and an alkane are contacted with each other in the presence of a solvent, said solvent does not constitute a superacid and the combination of said solvent with one or more of the reactants also does not give rise to a superacid.

A highly active catalyst supported molecular sieves-NaHCO3 mixture for the selective and advantageous N-monoalkylation of amines

Das, Asish R.,Medda, Arunima,Singha, Raghunath,Guchhait, Nikhil

experimental part, p. 841 - 848 (2010/06/01)

Amines are mono-N-alkylated by alkylmesylates in the presence of catalyst supported molecular sieves-NaHCO3 mixture in a regioselective, chemoselective and non-toxic process. Observed chemoselectivity is supported by 'DFT'.

PREPARATION AND UTILITY OF SUBSTITUTED INDOLES

-

Page/Page column 34, (2008/06/13)

Disclosed herein are substituted indoles of Formula I, processes of preparation there of, pharmaceutical compositions thereof, and methods of their use there of.

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