66-27-3 Usage
Description
Methyl methanesulfonate, also known as MMS, is a chemical compound with the formula CH3SO2OCH3. It is a colorless liquid with a strong, irritating odor. Methyl methanesulfonate is a potent alkylating agent that can form DNA adducts by adding methyl groups to specific sites on DNA bases, leading to mutations and other adverse effects.
Uses
Used in Chemical Research:
Methyl methanesulfonate is used as a mutagen and teratogen in experimental studies to investigate the mechanisms of DNA damage, repair, and mutagenesis. It is commonly employed in laboratory settings to induce genetic mutations in various organisms, including bacteria, yeast, and mammalian cells, to study the effects of DNA damage on cellular processes and to develop new strategies for DNA repair and mutagenesis prevention.
Used in Toxicology and Carcinogenesis Studies:
Methyl methanesulfonate is used as a brain carcinogen in toxicology and carcinogenesis research to study the effects of DNA alkylation on the development of brain tumors and to investigate the mechanisms of chemical-induced carcinogenesis. This helps researchers to better understand the molecular basis of cancer development and to identify potential therapeutic targets for the prevention and treatment of brain tumors.
Used in Environmental Monitoring:
Methyl methanesulfonate can be used as an environmental pollutant indicator in monitoring studies to assess the presence of hazardous chemicals in air, water, and soil samples. The detection of MMS in environmental samples can provide valuable information on the sources, distribution, and potential health risks associated with exposure to alkylating agents.
Used in Pharmaceutical Development:
Methyl methanesulfonate can be used as a tool compound in the development of new drugs and therapies targeting DNA repair mechanisms and cancer treatment. By studying the effects of MMS on DNA and cellular processes, researchers can gain insights into the molecular pathways involved in DNA damage response and develop new strategies for the prevention and treatment of cancer and other diseases associated with DNA damage.
Air & Water Reactions
Water soluble.
Reactivity Profile
Methyl methanesulfonate is incompatible with strong oxidizing agents, strong acids and strong bases.
Fire Hazard
Methyl methanesulfonate is combustible.
Safety Profile
Confirmed carcinogen
with carcinogenic and neoplastigenic data.
Poison by ingestion, intraperitoneal,
intravenous, and subcutaneous routes.
Human mutation data reported.
Experimental teratogenic and reproductive
effects. When heated to decomposition it
emits toxic fumes of SOx.
Potential Exposure
Research chemical and cancer drug.
No longer produced commercially in the United States.
Carcinogenicity
Methyl methanesulfonate is reascarcinogen based on sufficient evi
onably anticipated to be a human dence of carcinogenicity from studies in experimental animals.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
Purification Methods
Purify the ester by careful fractionation and collecting the middle fraction. Suspected CARCINOGEN. Note that MeSO3H has b 167-167.5o/10mm and methanesulfonic anhydride has b 138o/10mm)—both are possible impurities. [Beilstein 4 IV 11.]
Incompatibilities
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Esters are generally
incompatible with nitrates. Moisture may cause hydrolysis
or other forms of decomposition
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of lab chemicals or expired or waste drugs and pharmaceuticals by
flushing them down the toilet or discarding them to the
trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee
grounds, double-bagged in plastic, discard in trash.
Larger quantities shall carefully take into consideration
applicable DEA, EPA, and FDA regulations. If possible
return the pharmaceutical to the manufacturer for proper
disposal being careful to properly label and securely
package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported
by a state licensed medical waste contractor to dispose by
burial in a licensed hazardous or toxic waste landfill or
incinerator.
Check Digit Verification of cas no
The CAS Registry Mumber 66-27-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 66-27:
(4*6)+(3*6)+(2*2)+(1*7)=53
53 % 10 = 3
So 66-27-3 is a valid CAS Registry Number.
InChI:InChI=1/C2H6O3S/c1-5-6(2,3)4/h1-2H3
66-27-3Relevant articles and documents
King et al.
, p. 6304 (1971)
METHOD FOR THE PRODUCTION OF ALKANE SULFONIC ACID AT NON-SUPERACIDIC CONDITIONS
-
Page/Page column 12, (2020/10/09)
The present invention refers to a method for the production of alkane sulfonic acid, in which SO and an alkane are contacted with each other in the presence of a solvent, said solvent does not constitute a superacid and the combination of said solvent with one or more of the reactants also does not give rise to a superacid.
A highly active catalyst supported molecular sieves-NaHCO3 mixture for the selective and advantageous N-monoalkylation of amines
Das, Asish R.,Medda, Arunima,Singha, Raghunath,Guchhait, Nikhil
experimental part, p. 841 - 848 (2010/06/01)
Amines are mono-N-alkylated by alkylmesylates in the presence of catalyst supported molecular sieves-NaHCO3 mixture in a regioselective, chemoselective and non-toxic process. Observed chemoselectivity is supported by 'DFT'.
PREPARATION AND UTILITY OF SUBSTITUTED INDOLES
-
Page/Page column 34, (2008/06/13)
Disclosed herein are substituted indoles of Formula I, processes of preparation there of, pharmaceutical compositions thereof, and methods of their use there of.
