51534-41-9

Basic information

• Product Name: (E)-hexadec-2-enal
• CAS NO: 51534-41-9
• Molecular Weight: 238.414
• Mol File: 51534-41-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-hexadec-2-enal(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-hexadec-2-enal(51534-41-9)
• EPA Substance Registry System: (E)-hexadec-2-enal(51534-41-9)

Safety Data

• Hazardous Substances Data: 51534-41-9(Hazardous Substances Data)

Upstream product

• 26993-30-6 Sphingosine-1-phosphate 
• 26993-39-5 [(2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate 

Downstream Products

• 53939-28-9 (Z)-11-hexadecenal 
• 57-10-3 1-hexadecylcarboxylic acid 
• 536-14-1 N-palmitoyl-D-erythro-sphingomyelin 
• 2673-72-5 (2S,3R,E)-2-aminooctadec-4-ene-1,3-diol hydrochloride 
• 133859-59-3 (2R,5S,1'R,2'E)-2-(1'-Benzyloxymethoxy-hexadec-2'-en-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine 
• 103348-49-8 2-azido-sphingosine 
• 123-78-4 (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 
• 114299-64-8 (2S,3S,4E)-2-azido-3-O-(tert-butyldimethylsilyl)-4-octadecen-1,3-diol 
• 163013-14-7 (2R,3R)-(-)-N-(p-toluenesulfinyl)-2-carbomethoxy-3-(1-pentadecenyl)aziridine 
• 113507-74-7 (R)-(-)-2-carbomethoxy-3-(1-pentadecenyl)-2H-azirine 
• 143615-69-4 (2S,3S,4E)-2-N-acetylamino-1,3-dihydroxyoctadec-4-ene 
• 871259-09-5 t-butyl (2R,3S)-1-benzyl-3-(pentadec-1-enyl)aziridine-2-carboxylate 
• 871259-08-4 t-butyl (2R,3R)-1-benzyl-3-(pentadec-1-enyl)aziridine-2-carboxylate 
• 188299-19-6 (S,S)-1,3-dimethyl-4,5-diphenylimidazolidin-2-one 

Relevant articles and documents

The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA

Sphingosine 1-phosphate, a bioactive signaling molecule with diverse cellular functions, is irreversibly degraded by the endoplasmic reticulum enzyme sphingosine 1-phosphate lyase, generating trans-2-hexadecenal and phosphoethanolamine. We recently demonstrated that trans-2-hexadecenal causes cytoskeletal reorganization, detachment, and apoptosis in multiple cell types via a JNK-dependent pathway. These findings and the known chemistry of related α,β-unsaturated aldehydes raise the possibility that trans-2-hexadecenal may interact with additional cellular components. In this study, we show that it reacts readily with deoxyguanosine and DNA to produce the diastereomeric cyclic 1,. N2-deoxyguanosine adducts 3-(2-deoxy-β-d-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-8. R-hydroxy-6. R-tridecylpyrimido[1,2-a]purine-10(3. H)one and 3-(2-deoxy-β-d-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-8. S-hydroxy-6. S-tridecylpyrimido[1,2-a]purine-10(3. H)one. Thus, our findings suggest that trans-2-hexadecenal produced endogenously by sphingosine 1-phosphate lyase can react directly with DNA forming aldehyde-derived DNA adducts with potentially mutagenic consequences.

Creation of a S1P Lyase bacterial surrogate for structure-based drug design

S1P Lyase (SPL) has been described as a drug target in the treatment of autoimmune diseases. It plays an important role in maintaining intracellular levels of S1P thereby affecting T cell egress from lymphoid tissues. Several groups have already published approaches to inhibit S1P Lyase with small molecules, which in turn increase endogenous S1P concentrations resulting in immunosuppression. The use of structural biology has previously aided SPL inhibitor design. Novel construct design is at times necessary to provide a reagent for protein crystallography. Here we present a chimeric bacterial protein scaffold used for protein X-ray structures in the presence of early small molecule inhibitors. Mutations were introduced to the bacterial SPL from Symbiobacterium thermophilum which mimic the human enzyme. As a result, two mutant StSPL crystal structures resolved to 2.8 ? and 2.2 ? resolutions were solved and provide initial structural hypotheses for an isoxazole chemical series, whose optimization is discussed in the accompanying paper.