51537-87-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Nitrophenyl 1-Naphthylacetate is used as an intermediate for the synthesis of 1-Naphthylacetyl Spermine (N377800), which is a compound of interest in the pharmaceutical industry. The application reason is to facilitate the production of N377800, which may have potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-Nitrophenyl 1-Naphthylacetate is used as a key component in the preparation of various organic compounds. Its application reason is to serve as a building block for the creation of more complex molecules, which can be used in a wide range of industries, including pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 100-02-7 4-nitro-phenol 
• 86-87-3 naphth-1-yl acetic acid 

Downstream Products

• 773-99-9 2-naphthaleneethanol 

Relevant academic research and scientific papers

Synthesis of tripodal naphthylacetamide derivatives

Atripodalnaphthylacetamide derivative (land II) usedasanewenhancementfluorescence chemical sensor for detection of transition metal ions has been synthesized in this work. Two new derivatives were prepared in good yields according to the proposed method.

Isothiourea-catalyzed enantioselective α-alkylation of esters via 1,6-conjugate addition to para-quinone methides

The isothiourea-catalyzed enantioselective 1,6-conjugate addition of para-nitrophenyl esters to 2,6-disubstituted para-quinone methides is reported. para-Nitrophenoxide, generated in situ from initial N-acylation of the isothiourea by the para-nitrophenyl ester, is proposed to facilitate catalyst turnover in this transformation. A range of para-nitrophenyl ester products can be isolated, or derivatized in situ by addition of benzylamine to give amides at up to 99% yield. Although low diastereocontrol is observed, the diastereoisomeric ester products are separable and formed with high enantiocontrol (up to 94:6 er).

Enantioselective activation of stable carboxylate esters as enolate equivalents via N-heterocyclic carbene catalysts

The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed. The catalytically generated arylacetic ester enolates undergo enantioselective reactions with α,β-unsaturated imines.

Efficient and simple NaBH4 reduction of esters at cationic micellar surface

(Chemical Equation Presented) A simple, efficacious, and biocompatible methodology for reducing esters with sodium borohydride at an aqueous cationic micellar surface under ambient conditions has been developed. The present method holds promise for future use in selective functional group reduction and stereocontrolled alcohol synthesis.