5154-02-9

Usage

Uses

Used in Pharmaceutical Industry:
1,5-Isoquinolinediol is used as a reagent for the preparation of PARP inhibitors. It plays a crucial role in the development of PARP inhibitors, which are essential in the treatment of various types of cancer. As a potent inhibitor of PARP (IC50 = 0.39 μM), it helps in understanding the enzyme's function in DNA repair and apoptosis, contributing to the advancement of cancer therapeutics.
Used in Research and Development:
1,5-Isoquinolinediol is used as a research tool to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. It can be employed with cells in culture and in animal models to investigate the mechanisms of PARP inhibition and its potential applications in cancer treatment.

Biochem/physiol Actions

Cell permeable: yes

InChI:InChI=1/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)

Upstream product

• 144242-87-5 5-(benzyloxy)-1-hydroxyisoquinoline 
• 90347-99-2 5-Hydroxyisochinolin-2-oxid 

Downstream Products

• 118313-35-2 5-methoxyisoquinolin-1-ol 
• 56469-02-4 3,4-dihydro-5-hydroxy-1(2H)-isoquinolinone 
• 118313-35-2 5-methoxy-2H-isoquinoline-1-one 
• 762236-09-9 isoquinoline-1-oxide 
• 1190841-35-0 C₂₄H₂₅N₃O₄ 
• 144242-87-5 5-(benzyloxy)-1-hydroxyisoquinoline 
• 129075-87-2 3,4-dihydro-5-(3-chloropropoxy)-1(2H)-isoquinolinone 
• 106462-85-5 1-chloro-5-methyoxyisoquinoline 

Relevant academic research and scientific papers

Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds

Three synthetic routes were developed for structure-activity relationship (SAR) studies of HTS-derived isoquinolinone inhibitor probes for the orphan nuclear receptor steroidogenic factor-1 (NR5A1). Among the new analogs reported herein, 31 and 32 have im

Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process

The invention is selected, novel, and known analogs of isoquinolinones of the formula and pharmaceutically acceptable salts thereof; novel pharmaceutical compositions; and a method for enhancing the lethal effects for tumor cells to treatment having DNA damaging activity such as ionizing radiation or with chemotherapeutic agents.

Synthesis and Biological Activity of 4-(Diphenylmethyl)-α--1-piperazineethanol and Related Compounds

A series of 4-(diphenylmethyl)-α--1-piperazineethanol and closely related compounds was synthesised and evaluated for cardiac and vascular activity in isolated perfused rat and guinea pig hearts.Compound 1 produced greater inotropic effects in rat hearts than in guinea pig hearts, a phenomenon which was also observed with the prototype agent DPI 201-106.Compound 15 produced an inotropic effect with one-tenth the potency of compound 1.Both compounds 1 and 15 demonstrated direct inotropic and vasodilatory effects when administered iv in anesthetized dogs, although the vasodilatory activity was more pronounced with compound 15 than 1 and DPI compound.Compound 1 lacks the CN moiety which is a key structural requirement in DPI for positive inotropic activity.The synthesis, in vitro, and in vivo evaluations of these agents, and comparative data with DPI-201-106 (compound 17) are reported.