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5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 56469-02-4 Structure
  • Basic information

    1. Product Name: 5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
    2. Synonyms: 5-HYDROXY-1,2,3,4-TETRAHYDROISOQUINOLIN-1-ONE;5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;3,4-DIHYDRO-5-HYDROXY-1(2H)-ISOQUINOLINONE;5-hydroxy-3,4-dihydroisoquinolin-1(2H)-one
    3. CAS NO:56469-02-4
    4. Molecular Formula: C9H9NO2
    5. Molecular Weight: 163.17
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 56469-02-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 473.848 °C at 760 mmHg
    3. Flash Point: 240.375 °C
    4. Appearance: /
    5. Density: 1.282 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.604
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 9.23±0.20(Predicted)
    11. CAS DataBase Reference: 5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(56469-02-4)
    13. EPA Substance Registry System: 5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(56469-02-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 56469-02-4(Hazardous Substances Data)

56469-02-4 Usage

Uses

5-Hydroxy-3,4-dihydro-2H-isoquinolin-1-one is a useful research chemical.

Check Digit Verification of cas no

The CAS Registry Mumber 56469-02-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,4,6 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 56469-02:
(7*5)+(6*6)+(5*4)+(4*6)+(3*9)+(2*0)+(1*2)=144
144 % 10 = 4
So 56469-02-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-3,11H,4-5H2,(H,10,12)

56469-02-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

1.2 Other means of identification

Product number -
Other names 3,4-Dihydro-5-hydroxy-1(2H)-isoquinolinone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:56469-02-4 SDS

56469-02-4Relevant articles and documents

Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ2 receptors

Abate, Carmen,Selivanova, Svetlana V.,Müller, Adrienne,Kr?mer, Stefanie D.,Schibli, Roger,Marottoli, Roberta,Perrone, Roberto,Berardi, Francesco,Niso, Mauro,Ametamey, Simon M.

supporting information, p. 920 - 930 (2013/11/19)

σ2 Receptors are promising biomarkers for cancer diagnosis given the relationship between the proliferative status of tumors and their density. With the aim of contributing to the research of σ2 receptor Positron Emission Tomography (PET) probes, we developed 2-[3-[6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]propyl]-3, 4-dihydroisoquinolin-1(2H)-one (3), with optimal σ2 pharmacological properties and appropriate lipophilicity. Hence, 3 served as the lead compound for the development of a series of dihydroisoquinolinones amenable to radiolabeling. Radiosynthesis for compound 26, which displayed the most appropriate σ2 profile, was developed and σ2 specific binding for the corresponding [18F]-26 was confirmed by in vitro autoradiography on rat brain slices. Despite the excellent in vitro properties, [18F]-26 could not successfully image σ2 receptors in the rat brain in vivo, maybe because of its interaction with P-gp. Nevertheless, [18F]-26 may still be worthy of further investigation for the imaging of σ2 receptors in peripheral tumors devoid of P-gp overexpression.

Synthesis of 3,4-dihydro-1(2H)-isoquinolinones

Showalter,Sercel,Stier,Turner

, p. 961 - 964 (2007/10/03)

Approaches toward the preparative-scale synthesis of target 3,4-dihydro-1(2H)-isoquinolinones 1-3 are presented. Compounds 1 and 2 were prepared via a Schmidt rearrangement on easily obtained indanone precursors, but in low overall yield. A better method

Synthesis of 3,4-dihydro-5-[11C]methoxy-1(2H)-isoquinolinone as a Potential Tracer for Poly(ADP-ribose) Synthetase

Miyake, Yoshinori,Shimadzu, Hiroshi,Hashimoto, Naoto,Ishida, Yoshio,Shibakawa, Masahiko,Nishimura, Tsunehiko

, p. 983 - 988 (2007/10/03)

Synthesis of 3,4-dihydro-5-[11C]methoxy-1(2H)-isoquinolinone ([11C]MIQO), a potent poly (ADP-ribose) synthetase inhibitor, was devised in order to evaluate whether it is possible to image excessive activation of poly(ADP-ribose) synthetase (PARS) by positron emission tomography. [11C]MIQO was prepared by O-[11C]methylation of 3,4-dihydro-5-hydroxy-1(2H)-isoquinolinone, obtained by a Schmidt reaction with 4-hydroxy-1-indanone, sodium azide and trichloroacetic acid, with [11C]methyl triflate. Total synthesis time from EOB was 35 minutes. The radiochemical yield based on [11C]carbon dioxide was 31 +/- 8 percent (n=8; decay corrected). The final product had a specific activity of 76 GBq/umol at EOS, and the radiochemical purity of [11C]MIQO was over 99 percent.

Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process

-

, (2008/06/13)

The invention is selected, novel, and known analogs of isoquinolinones of the formula and pharmaceutically acceptable salts thereof; novel pharmaceutical compositions; and a method for enhancing the lethal effects for tumor cells to treatment having DNA damaging activity such as ionizing radiation or with chemotherapeutic agents.

BICYCLIC NITROGEN HETEROCYCLIC ETHERS AND THIOETHERS, AND THEIR PHARMACEUTICAL USES

-

, (2008/06/13)

A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including cytoprotective, H. sub.2-antagonist, anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions are disclosed.

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