51558-09-9

Basic information

• Product Name: 2-ethyl-2-(4-methoxyphenyl)butanenitrile
• Synonyms: 2-ethyl-2-(4-methoxyphenyl)butanenitrile
• CAS NO: 51558-09-9
• Molecular Weight: 203.284
• Mol File: 51558-09-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-ethyl-2-(4-methoxyphenyl)butanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethyl-2-(4-methoxyphenyl)butanenitrile(51558-09-9)
• EPA Substance Registry System: 2-ethyl-2-(4-methoxyphenyl)butanenitrile(51558-09-9)

Safety Data

• Hazardous Substances Data: 51558-09-9(Hazardous Substances Data)

Upstream product

• 75-03-6 ethyl iodide 
• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 1184761-90-7 3-(4-methoxyphenyl)pentan-3-amine 
• 1178318-30-3 2-ethyl-2-(4-methoxyphenyl)butanoic acid 
• 1356861-75-0 tert-butyl 4-{[3-(4-Methoxyphenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate 
• 1356862-07-1 benzyl [3-(4-methoxyphenyl)pentan-3-yl]carbamate 
• 1356861-93-2 N-[3-(4-methoxyphenyl)pentan-3-yl]-1-(2-phenylethyl)piperidine-4-carboxamide fumarate 
• 1356862-08-2 N-[3-(4-methoxyphenyl)pentan-3-yl]piperidine-4-carboxamide hydrochloride 

Relevant articles and documents

Synthesis and pharmacological evaluation of 1-Alkyl-N-[(1R)-1-(4- fluorophenyl)-2-methylpropyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents

We synthesized and evaluated inhibitory activity against T-type Ca 2+ channels for a series of 1-alkyl-N- [(1R)-1-(4-fluorophenyl)-2- methylpropyl]piperidine-4-carboxamide derivatives. Structure-activity relationship studies have revealed that the isopropyl substituent at the benzylic position plays an important role in exerting potent inhibitory activity, and the absolute configuration of the benzylic position was found to be opposite that of mibefradil, which was first launched as a new class of T-type Ca2+ channel blocker. Oral administration of N- [(1R)-1-(4-fluorophenyl)-2-methylpropyl]-1-[2-(3-methoxyphenyl)ethyl] piperidine-4-carboxamide (17f) lowered blood pressure in spontaneously hypertensive rats without inducing reflex tachycardia, an adverse effect often caused by traditional L-type Ca2+ channel blockers.