5156-22-9

Basic information

• Product Name: H-LEU-TRP-OH
• Synonyms: LEU-TRP;L-LEU-L-TRP 1/3 H2O;L-LEUCYL-L-TRYPTOPHAN;H-LEU-TRP-OH;FRAGMENT A;leu-trplighttancrystals;Leu-Trp-OH;L-Leu-L-Trp-OH
• CAS NO: 5156-22-9
• Molecular Formula: C17H23N3O3
• Molecular Weight: 317.38
• Product Categories: Dipeptides;Dipeptides and Tripeptides;Peptides
• Mol File: 5156-22-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 608.4°C at 760 mmHg
• Flash Point: 321.8°C
• Appearance: light tan/crystalline
• Density: 1.241g/cm³
• Vapor Pressure: 1.17E-15mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: −20°C
• CAS DataBase Reference: H-LEU-TRP-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-LEU-TRP-OH(5156-22-9)
• EPA Substance Registry System: H-LEU-TRP-OH(5156-22-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 5156-22-9(Hazardous Substances Data)

Usage

General Description

H-LEU-TRP-OH, also known as leucine tryptophan, is a dipeptide composed of the amino acids leucine and tryptophan. This chemical compound plays a crucial role in the human body, with leucine being an essential amino acid that is important for protein synthesis and muscle growth, while tryptophan is a precursor to the neurotransmitter serotonin and plays a key role in mood regulation. H-LEU-TRP-OH is widely used in pharmaceutical and biotechnological research and can be synthesized through various chemical processes for medicinal and research purposes. Its properties and functions are of great interest to scientists and researchers in the fields of biochemistry, medicine, and nutrition.

InChI:InChI=1/C17H23N3O3/c1-10(2)7-13(18)16(21)20-15(17(22)23)8-11-9-19-14-6-4-3-5-12(11)14/h3-6,9-10,13,15,19H,7-8,18H2,1-2H3,(H,20,21)(H,22,23)

Upstream product

• 36357-77-4 Talopeptin 
• 657377-74-7 DL-leucine-DL-tryptophan dipeptide 
• 61-90-5 L-leucine 
• 73-22-3 L-Tryptophan 

Downstream Products

• 56361-75-2 N-Phospho-L-leucyl-L-tryptophan 

Relevant articles and documents

Chiral HPLC Separation and Modeling of Four Stereomers of DL-Leucine-DL-Tryptophan Dipeptide on Amylose Chiral Column

Chiral high-performance liquid chromatography (HPLC) separation and modeling of four stereomers of DL-leucine-tryptophan DL-dipeptide on AmyCoat-RP column are described. The mobile phase applied was ammonium acetate (10?mM)-methanol-acetonitrile (50:5:45, v/v). The flow rate of the mobile phases was 0.8?mL/min with UV detection at 230?nm. The values of retention factors for LL-, DD-, DL-, and LD- stereomers were 2.25, 3.60, 5.00, and 6.50, respectively. The values of separation and resolution factors were 1.60, 1.39, and 1.30 and 7.76, 8.05, and 7.19. The limits of detection and quantitation were ranging from 1.0–2.3 and 5.6–14.0?μg/mL. The simulation studies established the elution orders and the mechanism of chiral recognition. It was seen that π–π connections and hydrogen bondings were the main forces for enantiomeric resolution. The reported chiral HPLC method may be applied for the enantiomeric separation of DL-leucine-DL-tryptophan in unknown matrices. Chirality 28:642–648, 2016.

Identification of novel L-amino acid α-ligases through hidden markov model-based profile analysis

L-Amino acid α-ligase (Lal), catalyzing the formation of α-dipeptides from unprotected l-amino acids in an ATP-dependent manner, is used in cost-effective fermentative production of dipeptides. We searched for novel Lals by in silico screening using Hidden Markov Model-based profile analysis, and identified five novel Lals that showed low similarity and different substrate specificity from known Lals.