5156-22-9

Usage

Uses

Used in Pharmaceutical Research:
H-LEU-TRP-OH is used as a research compound for studying the effects of amino acids on protein synthesis and muscle growth, as well as their role in mood regulation and neurotransmitter production.
Used in Biotechnological Research:
H-LEU-TRP-OH is used as a biotechnological tool for exploring the potential applications of dipeptides in the development of new therapeutic agents and understanding their mechanisms of action.
Used in Nutritional Supplements:
H-LEU-TRP-OH is used as an ingredient in nutritional supplements to support protein synthesis, muscle growth, and mood regulation, providing a direct source of essential amino acids for the body.
Used in Drug Development:
H-LEU-TRP-OH is used as a potential therapeutic agent in the development of medications targeting muscle wasting conditions, mood disorders, and other health issues related to amino acid deficiencies or imbalances.
Used in Food Industry:
H-LEU-TRP-OH can be used as a functional ingredient in food products to enhance their nutritional value and provide health benefits related to muscle growth and mood regulation.

InChI:InChI=1/C17H23N3O3/c1-10(2)7-13(18)16(21)20-15(17(22)23)8-11-9-19-14-6-4-3-5-12(11)14/h3-6,9-10,13,15,19H,7-8,18H2,1-2H3,(H,20,21)(H,22,23)

Upstream product

• 36357-77-4 Talopeptin 
• 61-90-5 L-leucine 
• 73-22-3 L-Tryptophan 
• 657377-74-7 DL-leucine-DL-tryptophan dipeptide 

Downstream Products

• 56361-75-2 N-Phospho-L-leucyl-L-tryptophan 

Relevant academic research and scientific papers

Chiral HPLC Separation and Modeling of Four Stereomers of DL-Leucine-DL-Tryptophan Dipeptide on Amylose Chiral Column

Chiral high-performance liquid chromatography (HPLC) separation and modeling of four stereomers of DL-leucine-tryptophan DL-dipeptide on AmyCoat-RP column are described. The mobile phase applied was ammonium acetate (10?mM)-methanol-acetonitrile (50:5:45, v/v). The flow rate of the mobile phases was 0.8?mL/min with UV detection at 230?nm. The values of retention factors for LL-, DD-, DL-, and LD- stereomers were 2.25, 3.60, 5.00, and 6.50, respectively. The values of separation and resolution factors were 1.60, 1.39, and 1.30 and 7.76, 8.05, and 7.19. The limits of detection and quantitation were ranging from 1.0–2.3 and 5.6–14.0?μg/mL. The simulation studies established the elution orders and the mechanism of chiral recognition. It was seen that π–π connections and hydrogen bondings were the main forces for enantiomeric resolution. The reported chiral HPLC method may be applied for the enantiomeric separation of DL-leucine-DL-tryptophan in unknown matrices. Chirality 28:642–648, 2016.

STRUCTURAL ELUCIDATION OF TALOPEPTIN (MK-I), A NOVEL METALLO PROTEINASE INHIBITOR PRODUCED BY STREPTOMYCES MOZUNENSIS MK-23

The structure of talopeptin (MK-I), a novel metallo proteinase inhibitor produced by Streptomyces mozunensis MK-23 was elucidated to be 6-deoxy-α-L-talopyranosyloxyphospo-L-leucyl-L-tryptophan.

Identification of novel L-amino acid α-ligases through hidden markov model-based profile analysis

L-Amino acid α-ligase (Lal), catalyzing the formation of α-dipeptides from unprotected l-amino acids in an ATP-dependent manner, is used in cost-effective fermentative production of dipeptides. We searched for novel Lals by in silico screening using Hidden Markov Model-based profile analysis, and identified five novel Lals that showed low similarity and different substrate specificity from known Lals.