515846-52-3

Upstream product

• 515846-36-3 (R)-[1-(2-{4-[5-(2,3-dichloro-4-hydroxy-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester 
• 74-88-4 methyl iodide 
• 515846-35-2 (R)-[1-(2-{4-[5-(2,3-dichloro-4-triisopropylsilanyloxy-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester 
• 515846-33-0 (R)-[1-(2-{4-[3-(2,3-dichloro-4-triisopropylsilanyloxy-phenyl)-3-oxo-prop-1-ynyl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester 
• 515846-30-7 2,3-dichloro-4-triisopropylsilanyloxy-benzoic acid 
• 515846-31-8 2,3-dichloro-4-triisopropylsilanyloxy-benzoyl chloride 
• 515846-27-2 (4-bromo-2,3-dichloro-phenoxy)-triisopropyl-silane 
• 738577-08-7 4-ethynylpiperidine 
• 550378-30-8 4-ethynylpiperidine hydrochloride salt 
• 550378-32-0 2-amino-1-(4-ethynyl-piperidin-1-yl)-ethanone; hydrochloride 
• 550378-31-9 [2-(4-ethynyl-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 287192-97-6 4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1940-44-9 4-bromo-2,3-dichlorophenol 
• 109803-52-3 1-bromo-2,3-dichloro-4-methoxybenzene 

Relevant academic research and scientific papers

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: An approach for inhibiting protein-protein interactions

Fragment assembly has shown promise for discovering small-molecule antagonists for difficult targets, including protein-protein interactions. Here, we describe a process for identifying a 60 nM inhibitor of the interleukin-2 (IL-2)/IL-2 receptor (IL-2Rα)

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

Using a site-directed fragment discovery method called tethering, we have identified a 60 nM small molecule antagonist of a cytokine/receptor interaction (IL-2/IL2Rα) with cell-based activity. Starting with a low micromolar hit, we employed a combination