51595-55-2Relevant articles and documents
'Wiring' of glucose oxidase and lactate oxidase within a hydrogel made with poly(vinyl pyridine) complexed with [Os(4,4′-dimethoxy-2,2′-bipyridine)2Cl]+/2+
Kenausis, Gregg,Taylor, Chris,Katakis, Ioanis,Heller, Adam
, p. 4131 - 4136 (1996)
Glucose and lactate electrodes based on hydrogels made by crosslinking glucose oxidase and the redox polymer formed upon complexing poly(vinyl pyridine) (PVP) with [Os(dmo-bpy)2Cl]+/2+ (dmo-bpy = 4,4′-dimethoxy-2,2′-bipyridine) on vitreous carbon electrode surfaces have been investigated. The redox potential of the hydrogels was +35 mV vs. SCE and their glucose electrooxidation current reached a plateau at +150 mV vs. SCE. Urate and acetaminophen were not electrooxidized at this potential at rates that would interfere with the glucose and lactate assays. At a glucose concentration of 1 mM, the addition of 0.1 mM ascorbate increased the current by 17%. At 5 mM glucose, switching the atmosphere from argon to oxygen reduced the currents by 11%.
Electrochemistry and spectroscopy of substituted [Ru(phen)3]2+ and [Ru(bpy)3]2+ complexes
van der Westhuizen, Deidré,von Eschwege, Karel G.,Conradie, Jeanet
, (2019/08/01)
The metal-to-ligand charge transfer property of nitrogen-based ruthenium complexes earns it a central place in dye-sensitized solar cell and photo-catalytic H2O and CO2 reduction research and applications. Electronic and spectral tuning are conveniently done by altering substituents and ligands. Cyclic voltammograms and UV–visible spectra of a synthesized series of electronically altered phenanthroline and bipyridyl ruthenium complexes (ΔE°' > 1.4 V for RuII-III) were obtained and, amongst others, correlated with DFT computed HOMO energies and ionization potentials. A good linear relationship with R2 = 0.97 were found for the combined bipyridyl and phenanthrolinato ruthenium series, thereby providing a convenient computational tool for the theoretical prediction of associated redox potentials. TDDFT closely simulates spectral properties of these complexes, where λmax varies from 420 to 520 nm. The former wavelength is representative of the dione-phenanthroline and the latter of the dinitro-bipyridyl ruthenium complex.
Synthesis and in vitro evaluation of diverse heterocyclic diphenolic compounds as inhibitors of DYRK1A
Zhou, Qingqing,Reekie, Tristan A.,Abbassi, Ramzi H.,Indurthi Venkata, Dinesh,Font, Josep S.,Ryan, Renae M.,Munoz, Lenka,Kassiou, Michael
, p. 5852 - 5869 (2018/11/10)
Dual-specificity tyrosine phosphorylation-related kinase 1A (DYRK1A) is a dual-specificity protein kinase that catalyses phosphorylation and autophosphorylation. Higher DYRK1A expression correlates with cancer, in particular glioblastoma present within the brain. We report here the synthesis and biological evaluation of new heterocyclic diphenolic derivatives designed as novel DYRK1A inhibitors. The generation of these heterocycles such as benzimidazole, imidazole, naphthyridine, pyrazole-pyridines, bipyridine, and triazolopyrazines was made based on the structural modification of the lead DANDY and tested for their ability to inhibit DYRK1A. None of these derivatives showed significant DYRK1A inhibition but provide valuable knowledge around the importance of the 7-azaindole moiety. These data will be of use for developing further structure-activity relationship studies to improve the selective inhibition of DYRK1A.
Ruthenium(II)–Pyridylimidazole Complexes as Photoreductants and PCET Reagents
Pannwitz, Andrea,Prescimone, Alessandro,Wenger, Oliver S.
supporting information, p. 609 - 615 (2017/02/05)
Complexes of the type [Ru(bpy)2pyimH]2+[bpy = 2,2′-bipyridine; pyimH = 2-(2-pyridyl)imidazole] with various substituents on the bpy ligands can act as photoreductants. Their reducing power in the ground state and in the long-lived3MLCT excited state is increased significantly upon deprotonation, and they can undergo proton-coupled electron transfer (PCET) in the ground and excited state. PCET with both the proton and electron originating from a single donor resembles hydrogen atom transfer (HAT) and can be described thermodynamically by formal bond dissociation free energies (BDFEs). Whereas the class of complexes studied herein has long been known, their N–H BDFEs have not been determined even though this is important in view of assessing their reactivity. Our study demonstrates that the N–H BDFEs in the3MLCT excited states are between 34 and 52 kcal mol–1depending on the chemical substituents at the bpy spectator ligands. Specifically, we report on the electrochemistry and PCET thermochemistry of three heteroleptic complexes in 1:1 (v/v) CH3CN/H2O with CF3, tBu, and NMe2substituents on the bpy ligands.
