51596-13-5Relevant academic research and scientific papers
Milbemycin derivatives: Modification at the C-5 position
Naito,Nanba,Owatari,Nakada,Muramatsu,Ide
, p. 233 - 242 (1994)
Protection of the hydroxyl group at the C-5 position of milbemycin A4 and D was carried out to investigate the influence of the C-5 hydroxyl group on the anthelmintic potency of these derivatives. Moreover, the hydroxyl group was converted into amide groups as bioisosters. Biological activities of these derivatives were measured against Nippostrongylus brasiliensis in vitro, and minimal concentrations which induce 100% immotility in worms were determined for each derivative. Biological testing revealed that the hydroxyl group at C-5 is a structural requirement for retaining anthelmintic activity.
Synthesis of milbemycins beta9 and beta10 from milbemycins A3 and A4 and their biological activities.
Tsukiyama, Takahiro,Kinoshita, Ayako,Ichinose, Reiji,Sato, Kazuo
, p. 1407 - 1411 (2007/10/03)
Chemical derivation methods were used to prepare milbemycins beta9 and beta10 from milbemycins A3 and A4. Their acaricidal activities were also assessed against the organophosphorus-sensitive two-spotted spider mite (Tetranychus urticae) on primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.
