51597-80-9

Basic information

• Product Name: N-((1H-indol-3-yl)methyl)aniline
• Synonyms: N-((1H-indol-3-yl)methyl)aniline
• CAS NO: 51597-80-9
• Molecular Weight: 222.29
• Mol File: 51597-80-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-((1H-indol-3-yl)methyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-((1H-indol-3-yl)methyl)aniline(51597-80-9)
• EPA Substance Registry System: N-((1H-indol-3-yl)methyl)aniline(51597-80-9)

Safety Data

• Hazardous Substances Data: 51597-80-9(Hazardous Substances Data)

Upstream product

• 108274-98-2 N-Phenyl-N-skatyl-hydroxylamin 
• 5457-28-3 3-cyano-1H-indole 
• 66003-76-7 Diphenyliodonium triflate 
• 17954-06-2 1H-indole-3-(N-phenyl)carboxamide 
• 103-01-5 N-Phenylglycine 
• 221044-05-9 N-(2-pyrimidyl)indole 
• 120-72-9 indole 
• 91-78-1 1,3,5-triphenylhexahydro-1,3,5-triazine 
• 2216-92-4 N-phenylglycine ethyl ester 
• 100-65-2 N-Phenylhydroxylamine 
• 19260-03-8 1-(1H-indol-3-yl)-N,N,N-trimethylmethanaminium methyl sulfate 
• 62-53-3 aniline 
• 487-89-8 Indole-3-carboxaldehyde 
• 22394-31-6 (E)-N-((1H-indol-3-yl)methylene)benzenamine 

Downstream Products

• 51597-83-2 3-[[N-(5-methyl-1-pyrrolin-2-yl)anilino]methyl] indole hydrochloride 
• 51597-87-6 3-[[N-(5,5-dimethyl-1-pyrrolin-2-yl)anilino]methyl]indole hydrochloride 
• 487-89-8 Indole-3-carboxaldehyde 
• 51596-88-4 (4,5-dihydro-3H-pyrrol-2-yl)-indol-3-ylmethyl-phenyl-amine 
• 51597-81-0 3-[[N-(1-pyrrolin-2-yl)anilino]methyl]indole hydrochloride 
• 83-34-1 3-Methylindole 

Relevant articles and documents

RhodiumIII/SilverI Relay Catalyzed C—H Aminomethylation with Imine Equivalents and Lewis Acid Catalyzed [4+2] Cycloaddition of Indoles with Triarylhexahydrotriazine?

A RhIII/AgI relay-catalyzed C(sp2)—H coupling of indoles with triarylhexahydrotriazine (THT) is reported in this context. Upon merging RhIII-catalyzed C(sp2)—H bond activation and silver promoted THT

Chemoselective Cu-catalyzed synthesis of diverseN-arylindole carboxamides, β-oxo amides andN-arylindole-3-carbonitriles using diaryliodonium salts

Chemoselective copper-catalyzed synthesis of diverseN-arylindole-3-carboxamides, β-oxo amides andN-arylindole-3-carbonitriles from readily accessible indole-3-carbonitriles, α-cyano ketones and diaryliodonium salts has been developed. DiverseN-arylindole-3-carboxamides and β-oxo amides were successfully achieved in high yields under copper-catalyzed neutral reaction conditions, and the addition of an organic base (DIPEA) resulted in a completely different selectivity pattern to produceN-arylindole-3-carbonitriles. Moreover, the importance of the developed methodology was realized by the synthesis of indoloquinolones andN-((1H-indol-3-yl)methyl)aniline and by a single-step gram-scale synthesis of the naturally occurring cephalandole A analogue.

Combining enzyme and photoredox catalysis for aminoalkylation of indoles: Via a relay catalysis strategy in one pot

We report a novel strategy for combining enzyme and visible-light for mild aminoalkylation of indoles. This method features a relay catalysis protocol consisting of enzyme-catalyzed hydrolysis, visible-light excited decarboxylation, and subsequent oxidiza