ALPHA-CORTOL, also known as α-Cortol, is a derivative of Cortisone, which is a glucocorticoid and an anti-inflammatory agent. It plays a crucial role in the regulation of various physiological processes in the body, including the immune response, inflammation, and metabolism.

516-38-1

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Basic information
1. Product Name: ALPHA-CORTOL
2. Synonyms: ALPHA-CORTOL;5-BETA-PREGNAN-3-ALPHA, 11-BETA, 17,20-ALPHA, 21-PENTOL;5BETA-PREGNAN-3ALPHA,11ALPHA,17ALPHA,20ALPHA,21-PENTOL;CORTOL;A-cortol crystalline;17-(1,2-dihydroxyethyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,11,17-triol;(20S)-5β-Pregnane-3α,11β,17,20,21-pentol
3. CAS NO:516-38-1
4. Molecular Formula: C₂₁H₃₆O₅
5. Molecular Weight: 368.51
6. EINECS: N/A
7. Product Categories: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
8. Mol File: 516-38-1.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: 564.5°Cat760mmHg
3. Flash Point: 255°C
4. Appearance: /
5. Density: 1.252g/cm³
6. Vapor Pressure: 4.28E-15mmHg at 25°C
7. Refractive Index: 1.586
8. Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
9. Solubility: DMSO (Slightly), Methanol (Slightly)
10. Stability: Hygroscopic
11. CAS DataBase Reference: ALPHA-CORTOL(CAS DataBase Reference)
12. NIST Chemistry Reference: ALPHA-CORTOL(516-38-1)
13. EPA Substance Registry System: ALPHA-CORTOL(516-38-1)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 516-38-1(Hazardous Substances Data)

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516-38-1 Usage

Uses

Used in Pharmaceutical Industry:
ALPHA-CORTOL is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain. It is particularly effective in treating conditions such as arthritis, asthma, and various skin disorders.
Used in Medical Applications:
ALPHA-CORTOL is used as a glucocorticoid in the treatment of various medical conditions, including autoimmune diseases, allergies, and adrenal insufficiency. Its immunosuppressive properties make it a valuable tool in managing severe inflammation and modulating the immune system.
Used in Research and Development:
ALPHA-CORTOL is used as a research compound for studying the effects of glucocorticoids on various biological processes. It helps researchers understand the mechanisms of action and potential therapeutic applications of these compounds in different diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 516-38-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 6 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 516-38:
(5*5)+(4*1)+(3*6)+(2*3)+(1*8)=61
61 % 10 = 1
So 516-38-1 is a valid CAS Registry Number.

InChI:InChI=1/C21H36O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-18,22-26H,3-11H2,1-2H3

516-38-1Synthetic route

: 2638-46-2
3α,20αF,21-triacetoxy-17-hydroxy-5β-pregnan-11-one

: 516-38-1
5β-pregnane-3α,11β,17α,20β,21-pentaol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride

: 95826-62-3
20α-cortol 20,21-diacetate

: 516-38-1
5β-pregnane-3α,11β,17α,20β,21-pentaol

Conditions

Conditions	Yield
saponification;

: 93206-77-0
methyl 20β-acetoxy-3α-tert-butyldimethylsilyloxy-17α-hydroxy-11-oxo-5β-pregnan-21-oate

: 516-38-1
5β-pregnane-3α,11β,17α,20β,21-pentaol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 410 mg / LiAlH4 / diethyl ether / 1 h / Ambient temperature 2: 250 mg / pyridine / Ambient temperature 3: 100 mg / 50percent H2SO4 / acetone / 0.17 h / Ambient temperature 4: saponification View Scheme

: 95826-65-6
20α-cortol 3-tert-butyldimethylsilyl ether

: 516-38-1
5β-pregnane-3α,11β,17α,20β,21-pentaol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 250 mg / pyridine / Ambient temperature 2: 100 mg / 50percent H2SO4 / acetone / 0.17 h / Ambient temperature 3: saponification View Scheme