51622-82-3

Upstream product

• 67-56-1 methanol 
• 105-39-5 chloroacetic acid ethyl ester 
• 1122-91-4 4-bromo-benzaldehyde 
• 96-34-4 methyl chloroacetate 
• 116-54-1 dichloroacetic acid methyl ester 

Downstream Products

• 1332831-64-7 C₁₁H₉BrO₂ 
• 1332831-63-6 6-(4-bromophenyl)-5,6-dihydropyran-2-one 
• 139618-70-5 Methyl trans-3-(4-bromophenyl)aziridine-2-carboxylate 
• 139618-91-0 (2S,3R)-1-(Biphenyl-4-carbonyl)-3-(4-bromo-phenyl)-aziridine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Regioselective syntheses of 3-hydroxy-4-aryl-3,4,5-trihydro-2H-benzo[b][1,4]diazepin-2(1H)-ones and 3-benzylquinoxalin-2(1H)-ones from arylglycidates when exposed to 1,2-diaminobenzenes

Representatives of two pharmacologically significant classes of compounds – 3-hydroxy-4-aryl-3,4,5-trihydro-2H-benzo[b][1,4]diazepin-2(1H)-ones and 3-benzylquinoxalin-2(1H)-ones – obtained in reactions of 1,2-diaminobenzenes with methyl 3-arylglycidates in boiling acetic acid. Substituents in arylglycidates determine the direction of processes. Electron withdrawing substituents (NO2), halogen atoms (Cl, Br, F), as well as the absence of substituents, provide the formation of benzo[b][1,4]diazepin-2(1H)-one derivatives, and electron donating groups (OMe, Me) contribute to the formation of 3-benzylquinoxalin-2(1H)-ones. As a result, a new rare representatives of 3-hydroxy-4-aryl-3,4,5-trihydro-2H-benzo[b][1,4]diazepin-2(1H)-ones were obtained and a new method for producing 3-benzylquinoxalin-2(1H)-ones has been proposed.

Dynamic kinetic asymmetric transformations of β-halo-α-keto esters by N,N′-dioxide/Ni(II)-catalyzed carbonyl-ene reaction

Dynamic kinetic asymmetric transformations of racemic β-halo-α-keto esters through carbonyl-ene reaction were realized using a chiral N,N′-dioxide-nickel(ii) complex, giving the corresponding β-halo-α-hydroxy esters containing two vicinal chiral tri- and tetrasubstituted carbon centers in good yields and dr with excellent ee values without the use of extra bases. Meanwhile, a proposed reaction mechanism was presented according to the configuration of the product.

N-Heterocyclic carbene-catalyzed cascade epoxide-opening and lactonization reaction for the synthesis of dihydropyrone derivatives

N-Heterocyclic carbene was employed as an efficient organic catalyst to catalyze a cascade epoxide-opening and lactonization reaction. This organocatalytic process could transform various readily accessible γ-epoxy-α,β-enals into dihydropyrone derivatives in good to excellent yields.

Multypodal tethers for high-density attachment of redox-active moieties to substrates

This invention provides redox-active molecules attached to polypodal (e.g., bipodal, tripodal, quadrapodal, pentapodal, etc.) tethers that can be used for attachment of the redox-active molecules to a substrate (e.g., an electrode). The tethered redox-active molecules are useful for the fabrication of memory devices.

Molecular structure of methyl phenylpyruvates studied by 1H NMR and IR spectroscopies and quantum mechanical calculations

Molecular structure of methyl phenylpyruvate (MPP) and its p-substituted derivatives has been investigated by 1H NMR and IR spectroscopies. The spectral data point out that MPPs take the enol form both in solution and in the solid state. The ab initio calculations were carried out in order to get information on the configurational and conformational preferences in the enol form. It is suggested from the calculation that the inter- and intra-molecular hydrogen bondings between the enol OH group and the ester C = O group are important for stabilization of the conformer.

Catalyst and method for isomerization

A catalyst for isomerization consisting essentially of a salt or complex salt represented by the formula: where M is a metal of Group IB, IIA, IIB or VIII of the periodic table, L is a ligand, Y is a conjugated base of a Bronsted acid, m is 0, 1, 2, 3 or 4 and n is 1, 2 or 3.