51627-99-7

Upstream product

• 16532-79-9 4-Bromophenylacetonitrile 
• 64-17-5 ethanol 

Downstream Products

• 1450838-42-2 phenyl[2-(4-bromobenzyl)-1H-1,3-benzimidazol-5-yl]methanone 
• 1547650-85-0 5,6-dichloro-2-(4-bromobenzyl)-1H-benzimidazole 
• 1557970-11-2 methyl [5,6-dichloro-2-(4-bromobenzyl)-1H-benzimidazole-1-yl]acetate 
• 1557970-20-3 2-[5,6-dichloro-2-(4-bromobenzyl)-1H-benzimidazole-1-yl]acetohydrazide 
• 1557969-83-1 2,2'-[2,2'-bis(4-bromobenzyl)-1H,1'H-5,5'-bibenzimidazole-1,1'-diyl]diacetate 
• 1557969-89-7 2,2'-[2,2'-bis(4-bromobenzyl)-1H,1'H-5,5'-bibenzimidazole-1,1'-diyl]diacetohydrazide 
• 69374-79-4 2-(4-bromophenyl)-2-oxoacetamide 
• 100622-41-1 2-(4-bromobenzyl)-1H-benzo[d]imidazole 

Relevant academic research and scientific papers

Copper(II)-Mediated Aerobic Oxidation of Benzylimidates: Synthesis of Primary α-Ketoamides

A simple and straightforward method for the synthesis of primary α-ketoamides has been discovered. The reaction represents the first example of benzylimidates directly converting to primary α-ketoamides by using sustainable molecular oxygen as an oxidant. This reaction proceeds in the presence of copper(II) salt via cleavage of benzylic C-H and C-O bonds of the benzylimidates with liberation of alcohols as the only byproduct. A wide substrate scope, operationally mild conditions, the use of single substrates, and a reaction scaled up to grams make this strategy very attractive and practical. Furthermore, mechanistic studies illustrate that the imidate group adjacent to the benzylic position plays crucial role in facilitating this chemical process.

Microwave-assisted synthesis of some new coumarin derivatives including 1,2,4-triazol-3-one and investigation of their biological activities

By using the microwave technology, a new protocol has been developed for the synthesis of new coumarin derivatives including 1,2,4-triazol-3-one skeleton. This protocol proves to be efficient and environmentally friendly in terms of easy work-up and good yields. All newly synthesized compounds were screened for their antimicrobial activity and lipase inhibition. Most of the compounds were found to be effective on Escherichia coli. N'-{[4-Amino-3-(2-bromobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2H-chromene-3-carbohydrazide and N'-{[4-amino-3-(3,4-dichlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2H-chromene-3-carbohydrazide had a good effect on lipase inhibition.

Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents

A library of eighty-six assorted benzimidazole derivatives was screened for antiviral activity against a panel of ten RNA and DNA viruses. Fifty-two of them displayed different levels of activity against one or more viruses, among which CVB-5, RSV, BVDV a

Microwave-assisted synthesis of some novel benzimidazole derivatives containing imine function and evaluation of their antimicrobial activity

4-Bromo-o-phenylenediamine and ethylimido-p-bromophenylacetate, 1, were subjected to microwave irradiation to synthesize benzimidazole derivative, compound 2. Ester derivative, 3, and hydrazide derivative, 4, of compound 2 were also synthesized, respectiv

Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives

This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. The structure of newly synthesized compounds was confirmed by 1H NMR and 13C NMR spectra. These compounds were screened for their lipase inhibition activity. Then, all compounds were evaluated with regard to pancreatic lipase activity, and some of the 2-substituted perimidines, bisperimidine and bisbenzimidazole derivatives showed lipase inhibition at various concentrations.

Efficient microwave assisted synthesis of some new benzimidazoles containing the mebendazole nucleus

A simple and practical method has been developed for the synthesis of benzimidazoles containing the biological active mebendazole nucleus. Iminoester hydrochlorides of phenylacetic acids were used as intermediates in the reaction with 3,4-diaminobenzophen