1547650-85-0Relevant academic research and scientific papers
Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents
Tonelli, Michele,Novelli, Federica,Tasso, Bruno,Vazzana, Iana,Sparatore, Anna,Boido, Vito,Sparatore, Fabio,La Colla, Paolo,Sanna, Giuseppina,Giliberti, Gabriele,Busonera, Bernardetta,Farci, Pamela,Ibba, Cristina,Loddo, Roberta
, p. 4893 - 4909 (2014)
A library of eighty-six assorted benzimidazole derivatives was screened for antiviral activity against a panel of ten RNA and DNA viruses. Fifty-two of them displayed different levels of activity against one or more viruses, among which CVB-5, RSV, BVDV a
Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity
Mentese, Emre,Bektas, Hakan,Uelker, Serdar,Bekircan, Olcay,Kahveci, Bahittin
, p. 64 - 68 (2014/03/21)
A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2- phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the synthesis of benzimidazoles, we synthesized ester and hydrazide derivatives under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and 3b, 3c, 5a and 6a showed lipase inhibition at various concentrations.
