516455-87-1 Usage
Uses
Used in Pharmaceutical Development:
1-(1-Isothiocyanato-Ethyl)-Adamantane is used as a key component in the development of new pharmaceuticals for its capacity to interact with specific targets within the body. Its isothiocyanate group allows for unique binding properties, which can be harnessed to create drugs with enhanced efficacy and selectivity.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(1-Isothiocyanato-Ethyl)-Adamantane serves as a valuable building block for designing and synthesizing novel chemical entities. Its rigid adamantane core and reactive isothiocyanate group facilitate the creation of compounds with diverse biological activities and potential therapeutic applications.
Used in Drug Delivery Systems:
1-(1-Isothiocyanato-Ethyl)-Adamantane can be employed in the development of innovative drug delivery systems, leveraging its unique structural properties to improve the bioavailability, targeting, and overall effectiveness of therapeutic agents.
Used in Chemical Synthesis:
1-(1-ISOTHIOCYANATO-ETHYL)-ADAMANTANE is also used as a versatile building block in chemical synthesis, allowing for the creation of a wide range of novel chemicals and materials with potential applications in various industries, including materials science, agrochemicals, and specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 516455-87-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,6,4,5 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 516455-87:
(8*5)+(7*1)+(6*6)+(5*4)+(4*5)+(3*5)+(2*8)+(1*7)=161
161 % 10 = 1
So 516455-87-1 is a valid CAS Registry Number.
516455-87-1Relevant academic research and scientific papers
Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships
Burmistrov, Vladimir,Saxena, Rahul,Pitushkin, Dmitry,Butov, Gennady M.,Chung, Fung-Lung,Aggarwal, Monika
supporting information, p. 6621 - 6633 (2021/05/29)
Mutant p53 rescue by small molecules is a promising therapeutic strategy. In this structure-activity relationship study, we examined a series of adamantyl isothiocyanates (Ad-ITCs) to discover novel agents as therapeutics by targeting mutant p53. We demonstrated that the alkyl chain connecting adamantane and ITC is a crucial determinant for Ad-ITC inhibitory potency. Ad-ITC 6 with the longest chain between ITC and adamantane displayed the maximum growth inhibition in p53R280K, p53R273H, or p53R306Stop mutant cells. Ad-ITC 6 acted in a mutant p53-dependent manner. It rescued p53R280K and p53R273H mutants, thereby resulting in upregulating canonical wild-type (WT) p53 targets and phosphorylating ATM. Ad-ISeC 14 with selenium showed a significantly enhanced inhibitory potency, without affecting its ability to rescue mutant p53. Ad-ITCs selectively depleted mutant p53, but not the WT, and this activity correlates with their inhibitory potencies. These data suggest that Ad-ITCs may serve as novel promising leads for the p53-targeted drug development.
Synthesis of Homologs of 1-Isothiocyanatoadamantane
Pitushkin,Burmistrov,Butov
, p. 1475 - 1479 (2019/01/04)
Amines of the adamantane series reacted with carbon disulfide and di-tert-butyl dicarbonate in the presence of triethylamine and a catalytic amount of 4-(dimethylamino)pyridine to give homologs of 1-isothiocyanatoadamantane in 80–86% yields. Adamantan-2-a
