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1501-84-4

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1501-84-4 Usage

Description

Rimantadine hydrochloride is an antiviral analogue of amantadine, reportedly useful in the prophylaxis and treatment of influenza A. Compared with amantadine, nmantadine appears to have a lower side-effect profile.

Chemical Properties

White Crystalline Solid

Originator

DuPont (USA)

Uses

Different sources of media describe the Uses of 1501-84-4 differently. You can refer to the following data:
1. Rimantadine Hydrochloride is used as an antiviral agent.
2. Used as an antiviral agent

Brand name

Flumadine (Forest);Roflual.

references

[1] koff w c, elm jr j l, halstead s b. suppression of dengue virus replication in vitro by rimantadine hydrochloride[j]. the american journal of tropical medicine and hygiene, 1981, 30(1): 184-189.[2] koff w c, peavy d l, knight v. inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[j]. infection and immunity, 1979, 23(3): 665-669.[3] hayden f g, monto a s. oral rimantadine hydrochloride therapy of influenza a virus h3n2 subtype infection in adults[j]. antimicrobial agents and chemotherapy, 1986, 29(2): 339-341.

Check Digit Verification of cas no

The CAS Registry Mumber 1501-84-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,0 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1501-84:
(6*1)+(5*5)+(4*0)+(3*1)+(2*8)+(1*4)=54
54 % 10 = 4
So 1501-84-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H

1501-84-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (R0070)  1-(1-Adamantyl)ethylamine Hydrochloride  >98.0%(N)

  • 1501-84-4

  • 5g

  • 495.00CNY

  • Detail
  • Alfa Aesar

  • (H53377)  1-(1-Adamantyl)ethylamine hydrochloride, 99%   

  • 1501-84-4

  • 5g

  • 834.0CNY

  • Detail
  • Alfa Aesar

  • (H53377)  1-(1-Adamantyl)ethylamine hydrochloride, 99%   

  • 1501-84-4

  • 25g

  • 3334.0CNY

  • Detail
  • USP

  • (1604508)  Rimantadinehydrochloride  United States Pharmacopeia (USP) Reference Standard

  • 1501-84-4

  • 1604508-300MG

  • 4,662.45CNY

  • Detail
  • Aldrich

  • (390593)  1-(1-Adamantyl)ethylaminehydrochloride  99%

  • 1501-84-4

  • 390593-1G

  • 772.20CNY

  • Detail

1501-84-4Downstream Products

1501-84-4Relevant articles and documents

Preparation method of rimantadine hydrochloride preparation

-

, (2019/02/04)

The invention discloses a preparation method of a rimantadine hydrochloride preparation. The preparation method comprises the following steps: preparation of 1-bromoadamantane, preparation of amantadecanoic acid, preparation of adamantanecarbonyl chloride, preparation of adamantyl methy ketone, preparation of 1-amantadine methyl ketone oxime, preparation of rimantadine hydrochloride, and preparation of the rimantadine hydrochloride preparation. The preparation of adamantyl methy ketone comprises the following steps: adding (CH3)3Sb and nickelous formate into a flask; dropwise adding an acetonitrile solution of adamantanecarbonyl chloride, wherein adamantanecarbonyl chloride reacts with (CH3)3Sb to generate adamantyl methy ketone; after reaction, pouring a reaction liquid into ice water; and filtering and drying the mixture to obtain a light yellow precipitate, thereby obtaining the adamantyl methy ketone. The preparation method has the beneficial effects that the preparation method ofrimantadine hydrochloride preparation is good in environmental protection, mild in condition of a synthetic method, simple and feasible in process and high in product yield.

A kind of anti-influenza virus preparation

-

, (2019/03/15)

The present invention discloses an anti-influenza virus preparation, including 1 - bromo adamantane preparation, adamantane formic acid preparation, adamantane chloride preparation, adamantane methyl preparation, 1 - adamantane methyl oxime preparation, hydrochloric acid rimantadine preparation, anti-influenza virus preparation, wherein the adamantane methyl preparation steps are as follows: in the flask to join the three trimethylaluminum, formic acid cerium, then dropwise adamantane formyl chloride [...], the adamantane chloride with three methyl aluminum reaction generating adamantane methyl ketone, after the reaction is completed in the reaction liquid into ice water, then filtering, drying, the resulting pale yellow precipitate adamantane methyl ketone. The beneficial effects: preparation method of this invention mild condition, the process is simple and feasible, high product yield, the system anti- influenza virus preparation can be effective prevention and treatment of type a/b influenza virus infection, also can effectively alleviate the symptoms of the common cold.

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