51646-39-0Relevant academic research and scientific papers
Pyrimido1,2,4-triazole-based LSD1 inhibitor, preparation method and applications thereof
-
, (2017/06/02)
The invention belongs to the field of medicinal chemistry, and discloses a pyrimido1,2,4-triazole-based LSD1 inhibitor, a preparation method and applications thereof. According to the present invention, a pyrimido1,2,4-triazole compound and a LSD1 compound are combined to prepare a series of antitumor activity compounds; the synthesis method is feasible, and the yield is high; the structure general formula of the compounds is defined in the specification, wherein R is amino, hydroxyethylpiperazinyl, morpholinyl, piperazinyl, p-fluoroanilino, p-methylanilino, anilino and the like; and with the applications of the compounds in the antitumor drugs using histone lysine specific demethylase (LSD1) as the target, the good activity is provided, and the new approach is developed for the novel antitumor drug using the LSD1 as the target.
2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines as adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitors with potential as new cardiovascular agents
Novinson,Springer,O'Brien,Scholten,Miller,Robins
, p. 420 - 426 (2007/10/02)
A series of new 2-(alkylthio)-5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines have been prepared as inhibitors of cAMP phosphodiesterase from various tissues. These derivatives were prepared via ring closure of various requisite 3-amino-1,2,4-triazole
2-SUBSTITUTED-S-TRIAZOLO[1,5A]-PYRIMIDINES
-
, (2008/06/13)
2-Substituted-s-triazolo[1,5a]pyrimidines are disclosed which are useful as inhibitors of phosphodiesterase enzymes or intermediates in the production process. Such comoounds are of the following structure: wherein X, R, R1, R2 and R3 are as defined herei
