516472-95-0Relevant articles and documents
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor
Baraldi, Pier Giovanni,Nu?ez, Maria del Carmen,Morelli, Anna,Falzoni, Simonetta,Di Virgilio, Francesco,Romagnoli, Romeo
, p. 1318 - 1329 (2007/10/03)
The P2X7 receptor is involved in several processes relevant to inflammation (cytokine release, NO generation, killing of intracellular pathogens, cytotoxicity); thus, it may be an appealing target for pharmacological intervention. The character