516484-10-9

Basic information

• Product Name: 8-((dimethylamino)methyl)-5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
• Synonyms: 8-((dimethylamino)methyl)-5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
• CAS NO: 516484-10-9
• Molecular Weight: 327.337
• Mol File: 516484-10-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-((dimethylamino)methyl)-5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-((dimethylamino)methyl)-5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one(516484-10-9)
• EPA Substance Registry System: 8-((dimethylamino)methyl)-5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one(516484-10-9)

Safety Data

• Hazardous Substances Data: 516484-10-9(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 491-67-8 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one 
• 124-40-3 dimethyl amine 

Relevant articles and documents

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Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that is associated with the elderly. The current therapy that is used to treat AD is based mainly on the administration of acetylcholinesterase (AChE) inhibitors. Due to their low eff

Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: Synthesis, SAR analysis, and biological activity

A series of nitrogen-containing flavonoid analogues were designed and synthesized by Mannich reaction, and screened for the inhibitory activities of cyclin-dependent kinases using a FRET-based biochemical assay method. The results showed that C-8 nitrogen-containing baicalein analogues 3a-3f exhibited potent CDK1/Cyclin B inhibitory activities. 5,6,7-Trihydroxy-8-(dimethylaminomethyl)-2-phenyl-4H-chromen-4-one 3a, 5,6,7-trihydroxy-8-(pyrrolid inylmethyl)-2-phenyl-4H-chromen-4-one 3b, and 5,6,7-trihydroxy-8-(piperidinylmethyl)-2-phenyl-4H-chromen-4-one 3c (IC50 1.05-1.28 μM) were about sixfold more potent than baicalein 2 (IC50 6.53 μM). 5,6,7-Trihydroxy-8-(morpholinomethyl)-2-phenyl-4H-chromen-4-one 3d, 5,6,7-trihydroxy-8-(thiomorpholinomethy)-2-phenyl-4H-chrom en-4-one 3e, and 5,6,7-trihydroxy-8-(4-methylpiperazinylmethyl)-2-phenyl-4H-chromen-4-one 3f (IC50 0.27-0.38 μM) were about 20-fold more potent than baicalein, and were at the same level as flavopiridol (IC50 0.33 μM).