51649-70-8

Upstream product

• 50427-77-5 5-amino-1-phenyl-1H-pyrazole-4-carboxamide 
• 108-24-7 acetic anhydride 
• 51649-80-0 5-amino-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 51649-69-5 5-acetylamino-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 5417-93-6 5-acetylamino-1-phenyl-1H-pyrazole-4-carboxylic acid amide 
• 158095-14-8 5-(4-Methoxy-phenyl)-6-methyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 64288-44-4 5-anilino-6-methyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 64257-07-4 5-amino-1,5-dihydro-6-methyl-1-phenyl-4H-pyrazolo<3,4-d>pyrimidin-4-one 
• 91974-63-9 6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4(5H)-one 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of novel pyrazolo-pyrimidinones as DPP-IV inhibitors in diabetes

We report the design, synthesis, biological activity and docking studies of series of novel pyrazolo[3,4-d]pyrimidinones as DPP-IV inhibitors in diabetes. Molecules were synthesized and evaluated for their DPP-IV inhibition activity. Compounds 5e, 5k, 5o and 6a were found to be potent inhibitors of DPP-IV enzyme. Amongst all the synthesized compounds, 6-methyl-5-(4-methylpyridin-2-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (5k) was found to be the most active based on in vitro DPP-IV studies and also exhibited promising in vivo blood glucose lowering activity in male Wistar rats.

Synthesis of some pyrazolopyrimidines

Some 1-phenyl-1H-6-(un)substituted-5-substituted-arylpyrazolopyrimidine-4(5H)-ones are synthesized by transformation of 6-methyl-1-phenyl-1H-pyrazolooxazin-4-ones and also from 5-amino-4-carbethoxy-1-phenyl pyrazole.