51656-05-4Relevant academic research and scientific papers
Simple method for the preparation of dialkyl (2,3-dihydro-1,3-thiazol-2-YL) -phosphonates
Janikowska, Karolina,Makowiec, Slawomir
experimental part, p. 12 - 20 (2011/03/20)
A simple synthesis of dialkyl (2,3-dihydro-1,3-thiazol-2-yl)-phosphonates from thiazolium salts and trialkyl phosphites is described. The series of dialkyl (2,3-dihydro-1,3-thiazol-2-yl)-phosphonates with various substituents in positions 3, 4, and 5 of the thiazole ring were prepared. However, only phosphonates with an aryl on the nitrogen atom were stable enough for chromatographic purification, although all the new phosphonates are very sensitive to oxidation. We made efforts to apply dialkyl (2,3-dihydro-1,3- thiazol-2-yl)-phosphonates in a Horner-Wadsworth-Emmons reaction, but the generated antiaromatic anion of phosphonate decomposed quickly, even at -70°C. Copyright Taylor & Francis Group, LLC.
Synthesis and heterocyclization of dithiocarbamoylacetoacetic esters and anilides
Dovlatyan,Eliazyan,Pivazyan,Ghazaryan,Engoyan,Grigoryan,Mirzoyan
, p. 593 - 597 (2007/10/03)
The action of salts of N-monosubstituted dithiocarbamic acids on α-chloroacetoacetic ester and the corresponding anilide led to the isolation of the α-dithiocarbamoyl derivatives. These derivatives are converted, on standing or heating, to the ethyl ester
